Simultaneous determination of pyridoxine hydrochloride and doxylamine succinate in tablets by HPTLC

被引：17

作者：

Argekar, AP ^{[1
]}

Sawant, JG ^{[1
]}

机构：

[1] Inst Sci, Dept Chem, Analyt Lab, Mumbai 400032, India

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 1999年 / 22卷 / 13期

关键词：

D O I：

10.1081/JLC-100101785

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new, simple, precise, accurate, rapid, and stability indicating high performance thin layer chromatography (HPTLC) method has been developed for the simultaneous determination of pyridoxine hydrochloride and doxylamine succinate in tablets. The stationary phase was silica gel 60F(254) HPTLC plates and the mobile phase was acetone chloroform - methanol - 25% ammonia solution (7 : 1.5 : 0.3 : 1.2, v/v). Detection and quantification was carried out densitometrically at 269 nm. The linearity ranges were 0.5-2.0 mu g/spot for both pyridoxine hydrochloride and doxylamine succinate. Assays for pyridoxine hydrochloride and doxylamine succinate were 10.20 mg/tab (RSD 0.73%) and 10.00 mg/tab (RSD 1.93%) respectively for the brand analyzed. Percentage recoveries of pyridoxine hydrochloride and doxylamine succinate were in the range of 99.30 - 103.00% and 97.70 - 101.00%, respectively.

引用

页码：2051 / 2060

页数：10

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