Inhibition of Chk1 Kinase Sensitizes Leukemia and Lymphoma Cell Lines with TP53 Mutations to Chemotherapy

被引:0
|
作者
Zemanova, Jana [1 ]
Sebejova, Ludmila [1 ]
Hylse, Ondrej [2 ]
Paruch, Kamil [2 ]
Pavlova, Sarka [1 ]
Mayer, Jiri [3 ,4 ]
Pospisilova, Sarka [1 ]
Trbusek, Martin [1 ]
机构
[1] Masaryk Univ, Cent European Inst Technol CEITEC, Brno, Czech Republic
[2] St Annes Univ Hosp, Ctr Biomol & Cellular Engn, Int Clin Res Ctr, Brno, Czech Republic
[3] Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno, Czech Republic
[4] Masaryk Univ, Fac Med, Brno, Czech Republic
关键词
D O I
10.1182/blood.V120.21.2460.2460
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
2460
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Involving Cerebrospinal Fluid (CSF) Shows Pathogenic TP53 Mutations
    Shestakova, Anna
    Haghighu, Nahideh
    Souccar, Sami
    Zhao, Xiaohui
    Chan, Jefferson
    Rezk, Sherif
    LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 1383 - 1384
  • [42] Inhibition of CHK1 sensitizes Ewing sarcoma cells to CDK1-dependent cell death in S-phase
    Gordon, David
    Goss, Kelli
    Koppenhafer, Stacia
    CANCER RESEARCH, 2019, 79 (13)
  • [43] A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines
    Inukai, Takeshi
    Zhang, Xiuru
    Kameyama, Takeshi
    Suzuki, Yukiko
    Yoshikawa, Kazuhito
    Kuroda, Itaru
    Nemoto, Atsushi
    Akahane, Koshi
    Sato, Hiroki
    Goi, Kumiko
    Nakamoto, Kazunori
    Hamada, Jun-ichi
    Tada, Mitsuhiro
    Moriuchi, Tetsuya
    Sugita, Kanji
    AMERICAN JOURNAL OF HEMATOLOGY, 2010, 85 (07) : 535 - 537
  • [44] Frequent RUNX1 and TP53 Mutations in Secondary Acute Myeloid Leukemia with Mixed Phenotype
    Galera, Pallavi
    Baik, Jeeyeon
    Famulare, Christopher
    Sigler, Allison
    Zhang, Yanming
    Arcila, Maria
    Dogan, Ahmet
    Tallman, Martin
    Levine, Ross
    Glass, Jacob
    Roshal, Mikhail
    Xiao, Wenbin
    MODERN PATHOLOGY, 2020, 33 (SUPPL 2) : 1293 - 1294
  • [45] Frequent RUNX1 and TP53 Mutations in Secondary Acute Myeloid Leukemia with Mixed Phenotype
    Galera, Pallavi
    Baik, Jeeyeon
    Famulare, Christopher
    Sigler, Allison
    Zhang, Yanming
    Arcila, Maria
    Dogan, Ahmet
    Tallman, Martin
    Levine, Ross
    Glass, Jacob
    Roshal, Mikhail
    Xiao, Wenbin
    LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 1293 - 1294
  • [46] BUB1 Inhibition Sensitizes TNBC Cell Lines to Chemotherapy and Radiotherapy
    Sriramulu, Sushmitha
    Thoidingjam, Shivani
    Siddiqui, Farzan
    Brown, Stephen L.
    Movsas, Benjamin
    Walker, Eleanor
    Nyati, Shyam
    BIOMOLECULES, 2024, 14 (06)
  • [47] HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1
    Busch, Chia-Jung
    Kriegs, Malte
    Laban, Simon
    Tribius, Silke
    Knecht, Rainald
    Petersen, Cordula
    Dikomey, Ekkehard
    Rieckmann, Thorsten
    RADIOTHERAPY AND ONCOLOGY, 2013, 108 (03) : 495 - 499
  • [48] TP53 Mutations are Common in Mantle Cell Lymphoma, Including the Indolent Leukemic Non-Nodal Variant
    Sakhdari, Ali
    Patel, Keyur
    Ok, Chi Young
    Kanagal-Shamanna, Rashmi
    Yin, C. Cameron
    Zuo, Zhuang
    Hu, Shimin
    Routbort, Mark
    Luthra, Rajyalakshmi
    Medeiros, L. Jeffrey
    Khoury, Joseph
    Loghavi, Sanam
    LABORATORY INVESTIGATION, 2018, 98 : 549 - 549
  • [49] TP53 Mutations are Common in Mantle Cell Lymphoma, Including the Indolent Leukemic Non-Nodal Variant
    Sakhdari, Ali
    Patel, Keyur
    Ok, Chi Young
    Kanagal-Shamanna, Rashmi
    Yin, C. Cameron
    Zuo, Zhuang
    Hu, Shimin
    Routbort, Mark
    Luthra, Rajyalakshmi
    Medeiros, L. Jeffrey
    Khoury, Joseph
    Loghavi, Sanam
    MODERN PATHOLOGY, 2018, 31 : 549 - 549
  • [50] Frequency, Spectrum, and Functional Significance of TP53 Mutations in Patients with Diffuse Large B-Cell Lymphoma
    Voropaeva, E. N.
    Pospelova, T. I.
    Voevoda, M. I.
    Maksimov, V. N.
    MOLECULAR BIOLOGY, 2017, 51 (01) : 53 - 60