Glucagon-like peptide 2

被引：43
|
作者：
Drucker, DJ [1 ]
机构：
[1] Univ Toronto, Toronto Hosp, Banting & Best Diabet Ctr, Toronto, ON M5G 2C4, Canada
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 04期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S1043-2760(98)00136-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Glucagon-like peptide 2 (GLP-2) is secreted in a nutrient-dependent manner from enteroendocrine cells throughout the gastrointestinal tract and is trophic to the intestinal epithelial mucosa. GLP-2 acts via stimulation of crypt cell proliferation and inhibition of cell death. GLP-2 also stimulates intestinal glucose transport, decreases mucosal permeability, and shows therapeutic efficacy in experimental models of short bowel syndrome and both small and large bowel inflammation.
引用
收藏
页码：153 / 156
页数：4
相关论文
共 50 条
  • [41] Structural determinants for activity of glucagon-like peptide-2
    DaCambra, MP
    Yusta, B
    Sumner-Smith, M
    Crivici, A
    Drucker, DJ
    Brubaker, PL
    BIOCHEMISTRY, 2000, 39 (30) : 8888 - 8894
  • [42] Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1
    Furness, S. G. B.
    Christopoulos, A.
    Sexton, P. M.
    Wootten, D.
    BIOCHEMICAL PHARMACOLOGY, 2018, 156 : 223 - 240
  • [43] Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
    Orskov, C
    Poulsen, SS
    Moller, M
    Holst, JJ
    DIABETES, 1996, 45 (06) : 832 - 835
  • [44] METABOLIC RESPONSE OF TELEOST HEPATOCYTES TO GLUCAGON-LIKE PEPTIDE AND GLUCAGON
    MOMMSEN, TP
    MOON, TW
    JOURNAL OF ENDOCRINOLOGY, 1990, 126 (01) : 109 - 118
  • [45] Glucagon-like peptide 2 (GLP-2), an intestinotrophic mediator
    Thulesen, J
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2004, 5 (01) : 51 - 65
  • [46] GLUCAGON AND GLUCAGON-LIKE PEPTIDE FROM PHYLOGENETICALLY ANCIENT FISH
    CONLON, JM
    MOMMSEN, TP
    YOUSON, JH
    DIGESTION, 1993, 54 (06) : 368 - 368
  • [47] Colonic Dysplasia Is Increased By Glucagon-Like Peptide-2 in Azoxymethane-Treated Mice and Is Decreased By Antagonism of the Glucagon-Like Peptide-2 Receptor
    Iakoubov, Roman
    Lauffer, Lina
    Trivedi, Shivangi
    Sie, Karen Kai Yi
    Kim, Young-In J.
    Brubaker, Patricia L.
    GASTROENTEROLOGY, 2009, 136 (05) : A754 - A754
  • [48] Glucagon, glucagon-like peptide-1 and their receptors: An introduction
    Holst, JJ
    ACTA PHYSIOLOGICA SCANDINAVICA, 1996, 157 (03): : 309 - 315
  • [49] Stability of glucagon-like peptide 1 and glucagon in human plasma
    Albrechtsen, Nicolai J. Wewer
    Bak, Monika J.
    Hartmann, Bolette
    Christensen, Louise Wulff
    Kuhre, Rune E.
    Deacon, Carolyn F.
    Holst, Jens J.
    ENDOCRINE CONNECTIONS, 2015, 4 (01):
  • [50] EFFECT OF GLUCAGON ON SECRETION OF GLUCAGON-LIKE PEPTIDE-1
    SHIMA, K
    OHBOSHI, C
    SATO, M
    HIROTA, M
    HORMONE AND METABOLIC RESEARCH, 1988, 20 (02) : 123 - 124
12345