The cdk2 binding domain of p27(Kip) correlates with the inhibition of the kinase activity of cdk2/cyclin complexes

被引：9

作者：

Kwon, TK ^{[1
]}

Buchholz, MA ^{[1
]}

Nordin, AA ^{[1
]}

机构：

[1] NIA,CLIN IMMUNOL SECT,CTR GERONTOL RES,NIH,BALTIMORE,MD 21224

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 220卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.0468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cyclin-dependent kinase inhibitor p27(Kip) binds to cyclin/cyclin-dependent kinases and preferentially inhibits the catalytic activity of cdk2 and cdk4. The cdk2 binding domain of p27(Kip) was determined using a series of N-terminal truncated and point mutations of GST-p27(Kip). The binding domain was contained within amino acid residues 53-85. The inhibition of the catalytic activity of preformed functional cdk2/cyclin complexes by p27(Kip) was also associated with the binding domain.

引用

页码：703 / 709

页数：7

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