Ferrocenylchalcone-uracil conjugates: synthesis and cytotoxic evaluation

被引：6

作者：

Singh, Amandeep ^{[1
]}

Mehra, Vishu ^{[2
]}

Sadeghiani, Neda ^{[3
]}

Mozaffari, Saghar ^{[3
]}

Parang, Keykavous ^{[3
]}

Kumar, Vipan ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India

[2] Hindu Coll, Dept Chem, Amritsar 143001, Punjab, India

[3] Chapman Univ, Sch Pharm, Ctr Targeted Drug Delivery, Irvine, CA 92618 USA

来源：

MEDICINAL CHEMISTRY RESEARCH | 2018年 / 27卷 / 04期

关键词：

Click chemistry; Cytotoxic evaluation; Ferrocenylchalcone; Uracil; ANTI-TUBERCULAR EVALUATION; BETA-LACTAM-FERROCENE; ANTICANCER AGENTS; CANCER; CELLS; DERIVATIVES; CHEMISTRY;

D O I：

10.1007/s00044-018-2145-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Huisgen's azide-alkyne cycloaddition reaction was employed to synthesize a series of 1H-1,2,3-triazole-tethered uracil-ferrocenyl chalcone conjugates with the aim of evaluating their in vitro anti-proliferative efficacy on human leukemia (CCRF-CEM) and human breast adenocarcinoma (MDA-MB-468) cell lines. Cytotoxic evaluation studies identified a number of synthesized conjugates that inhibited the proliferation of leukemia cancer cells by similar to 70% after 72 h. The selected synthesized conjugates were found to be significantly less cytotoxic against normal kidney cell line (LLC-PK1) when compared with CCRF-CEM cancer cells. [GRAPHICS] .

引用

页码：1260 / 1268

页数：9

共 50 条

[41] Synthesis and cytotoxic evaluation of combretafurazans
Tron, GC
Pagliai, F
Del Grosso, E
Genazzani, AA
Sorba, G
JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (09) : 3260 - 3268
[42] Ramoplanin Imaging Conjugates - Synthesis and Evaluation
Sheikh, Sumbla
Sturzu, Alexander
Kalbacher, Hubert
Klose, Uwe
Naegele, Thomas
Amin, Bushra
Deeg, Martin
Horger, Marius
Ernemann, Ulrike
Heckl, Stefan
MEDICINAL CHEMISTRY, 2014, 10 (01) : 18 - 26
[43] Stereoselective synthesis of novel uracil polyoxin C conjugates as substrate analogues of chitin synthase
Plant, Andrew
Thompson, Peter
Williams, David M.
JOURNAL OF ORGANIC CHEMISTRY, 2008, 73 (10): : 3714 - 3724
[44] Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity
Wei-bin Mo
Chun-hua Su
Jia-yan Huang
Jun Liu
Zhen-feng Chen
Ke-guang Cheng
Chemistry Central Journal, 10
[45] Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity
Mo, Wei-bin
Su, Chun-hua
Huang, Jia-yan
Liu, Jun
Chen, Zhen-feng
Cheng, Ke-guang
CHEMISTRY CENTRAL JOURNAL, 2016, 10
[46] 7-Chloroquinoline-isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation
Raj, Raghu
Biot, Christophe
Carrere-Kremer, Severine
Kremer, Laurent
Guerardel, Yann
Gut, Jiri
Rosenthal, Philip J.
Forge, Delphine
Kumar, Vipan
CHEMICAL BIOLOGY & DRUG DESIGN, 2014, 83 (05) : 622 - 629
[47] Synthesis and cytotoxic activity of conjugates of muramyl and normuramyl dipeptides with batracylin derivatives
Dzierzbicka, K
Trzonkowski, P
Sewerynek, P
Mysliwski, A
JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (06) : 978 - 986
[48] Synthesis of berberine-piperazine conjugates as potential antioxidant and cytotoxic agents
Bhupendra Mistry
Young Soo Keum
Muthuraman Pandurangan
Rahul V. Patel
Doo Hwan Kim
Medicinal Chemistry Research, 2016, 25 : 2461 - 2470
[49] Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates
Sun, Hua
Yue, Partick Y. K.
Wang, Shao-Rong
Huo, Lihong
Zhao, Ying
Xie, Songbo
Kringelum, Jens V.
Lund, Ole
Taboureau, Olivier
Zhou, Jun
Wong, Ricky N. S.
Fang, Wei-Shuo
MEDICINAL CHEMISTRY, 2016, 12 (08) : 775 - 785
[50] Synthesis of berberine-piperazine conjugates as potential antioxidant and cytotoxic agents
Mistry, Bhupendra
Keum, Young Soo
Pandurangan, Muthuraman
Patel, Rahul V.
Kim, Doo Hwan
MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (11) : 2461 - 2470

← 1 2 3 4 5 →