Ferrocenylchalcone-uracil conjugates: synthesis and cytotoxic evaluation

被引：6

作者：

Singh, Amandeep ^{[1
]}

Mehra, Vishu ^{[2
]}

Sadeghiani, Neda ^{[3
]}

Mozaffari, Saghar ^{[3
]}

Parang, Keykavous ^{[3
]}

Kumar, Vipan ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India

[2] Hindu Coll, Dept Chem, Amritsar 143001, Punjab, India

[3] Chapman Univ, Sch Pharm, Ctr Targeted Drug Delivery, Irvine, CA 92618 USA

来源：

MEDICINAL CHEMISTRY RESEARCH | 2018年 / 27卷 / 04期

关键词：

Click chemistry; Cytotoxic evaluation; Ferrocenylchalcone; Uracil; ANTI-TUBERCULAR EVALUATION; BETA-LACTAM-FERROCENE; ANTICANCER AGENTS; CANCER; CELLS; DERIVATIVES; CHEMISTRY;

D O I：

10.1007/s00044-018-2145-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Huisgen's azide-alkyne cycloaddition reaction was employed to synthesize a series of 1H-1,2,3-triazole-tethered uracil-ferrocenyl chalcone conjugates with the aim of evaluating their in vitro anti-proliferative efficacy on human leukemia (CCRF-CEM) and human breast adenocarcinoma (MDA-MB-468) cell lines. Cytotoxic evaluation studies identified a number of synthesized conjugates that inhibited the proliferation of leukemia cancer cells by similar to 70% after 72 h. The selected synthesized conjugates were found to be significantly less cytotoxic against normal kidney cell line (LLC-PK1) when compared with CCRF-CEM cancer cells. [GRAPHICS] .

引用

页码：1260 / 1268

页数：9

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