Nationwide surveillance study of human astrovirus infections in an Italian paediatric population

被引：31
|
作者：
De Grazia, S. [1 ]
Martella, V. [2 ]
Chironna, M. [3 ]
Bonura, F. [1 ]
Tummolo, F. [4 ]
Calderaro, A. [4 ]
Moschidou, P. [2 ]
Giammanco, G. M. [1 ]
Medici, M. C. [4 ]
机构：
[1] Univ Palermo, Dipartimento Sci Promoz Salute G DAlessandro, I-90127 Palermo, Italy
[2] Univ Aldo Moro Bari, Dipartimento Sanita Pubbl & Zootecnia, Bari, Italy
[3] Univ Aldo Moro Bari, Dipartimento Sci Biomed, Sez Igiene, Bari, Italy
[4] Univ Parma, Dipartimento Patol & Med Lab, Sez Microbiol, I-43100 Parma, Italy
来源：
EPIDEMIOLOGY AND INFECTION | 2013年 / 141卷 / 03期
关键词：
Astroviruses; epidemiology; gastroenteritis; virology (human); MOLECULAR EPIDEMIOLOGY; ACUTE GASTROENTERITIS; CHILDREN; PERIOD; BRAZIL;
D O I：
10.1017/S0950268812000945
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The study investigated the genetic diversity of human astroviruses (HAstVs) detected in children hospitalized with gastroenteritis in Italy in 2008-2009. A total of 1321 faecal samples were collected in Parma (northern Italy), Bari (southern Italy), and Palermo (Sicily) and screened for the presence of HAstVs. RT-PCR amplification of a portion at the 5'-end of ORF2 allowed the detection of HAstVs in 3.95% of the patients. Four different genotypes (HAstV-1, HAstV-2, HAstV-4, HAstV-5) were found to be circulating during the study period, with HAstV-1 being the predominant type. Interestingly, a novel lineage, proposed as HAstV-2d, was found to have emerged in Parma in 2009. Investigating the genetic variability of HAstVs will be important for understanding the epidemiological trends and evolution of these viruses.
引用
收藏
页码：524 / 528
页数：5
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