Cytokines and Chemokines Modulation of Itch

被引：10

作者：

Du, Li-Xia ^{[1
]}

Zhu, Jian-Yu ^{[2
]}

Mi, Wen-Li ^{[2
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Sch Basic Med Sci, Shanghai 201203, Peoples R China

[2] Fudan Univ, Shanghai Key Lab Acupuncture Mech & Acupoint Func, Dept Integrat Med & Neurobiol,Sch Basic Med Sci, Inst Brain Sci,Shanghai Med Coll,Inst Integrat Me, Shanghai 200032, Peoples R China

来源：

NEUROSCIENCE | 2022年 / 495卷

关键词：

itch; cytokines; chemokines; skin diseases; neuromodulators; INNATE LYMPHOID-CELLS; ATOPIC-DERMATITIS; INTERLEUKIN-31; RECEPTOR; BARRIER DYSFUNCTION; SCRATCHING BEHAVIOR; SENSORY NEURONS; MEDIATES ITCH; MURINE MODEL; T-CELLS; PRURITUS;

D O I：

10.1016/j.neuroscience.2022.05.035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Itch (pruritus) is a common cutaneous symptom widely associated with many skin complaints, and chronic itch can be a severe clinical problem. The onset and perpetuation of itch are linked to cytokines, such as interleukin (IL)-31, IL-4, IL-13, IL-33, thymic stromal lymphopoietin, and tumor necrosis factor-alpha, and chemokines, such as chemokine (C-C motif) ligand 2 and C-X-C motif chemokine ligand 10. This review highlights research that has attempted to determine the attributes of various cytokines and chemokines concerning the development and modulation of itch. Through such research, clinical approaches targeting cytokines and/or chemokines may arise, which may further the development of itch therapeutics. (C) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：74 / 85

页数：12

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