A facile route for the preparation of disubstituted 1,3,4-oxadiazoles from furfural, carboxylic acids, and secondary amines in the presence of N-isocyaniminotriphenylphosphorane

被引：0
|
作者：
Ramazani, Ali [1 ]
Fattahi, Nadia [1 ]
Rezaei, Aram [1 ]
Nasrabadi, Fatemeh Zeinali [1 ]
机构：
[1] Univ Zanjan, Dept Chem, Zanjan, Iran
来源：
CHEMIJA | 2012年 / 23卷 / 03期
关键词：
N-isocyaniminotriphenylphosphorane; furfural; carboxylic acid; 1,3,4-oxadiazole; aza-Wittig reaction; secondary amine; ONE-POT; 4-COMPONENT SYNTHESIS; MULTICOMPONENT REACTIONS; 3-COMPONENT REACTION; (E)-CINNAMIC ACIDS; DERIVATIVES; (N-ISOCYANIMINO)TRIPHENYLPHOSPHORANE; ISOCYANIDE;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple method has been developed for four-component synthesis of disubstituted 1,3,4-oxadiazoles using N-isocyaniminotriphenylphosphorane, a secondary amine, carboxylic acid, and furfural in CH2Cl2 by a Ugi-4CR/aza-Wittig sequence at room temperature in fairly high yields without using any catalyst or activation. The procedure provides an alternative method to the preparation of fully substituted 1,3,4-oxadiazoles.
引用
收藏
页码：255 / 261
页数：7
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