Mirtazapine-induced restless legs

Two cases of restless legs syndrome in association with mirtazapine treatment of 5-6 weeks are presented. Rather than akathisia related to serotonine reuptake inhibitors, which usually emerges during the first weeks of treatment, our cases resemble previously described mianserin-induced RLS cases. This suggests that although blockade of 5-HT2 receptors by mirtazapine may be protective against acute akathisia, it does not protect against slowly developing restless legs syndrome similar to that induced by mianserin. (C) 1997 John Wiley & Sons, Ltd.