Combinatorial control of gene expression by nuclear receptors and coregulators

被引：1190

作者：

McKenna, NJ ^{[1
]}

O'Malley, BW ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

CELL | 2002年 / 108卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(02)00641-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear receptor (NR) superfamily of transcription factors regulates gene expression in response to endocrine signaling, and recruitment of coregulators affords these receptors considerable functional flexibility. We will place historical aspects of NR research in context with current opinions on their mechanism of signal transduction, and we will speculate upon future trends in the field.

引用

页码：465 / 474

页数：10

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