Synthesis of 5-heterocyclic substituted quinazolin-4-ones via 2-aminobenzonitrile derivatives

被引：0

作者：

Fray, MJ ^{[1
]}

Allen, P ^{[1
]}

Bradley, PR ^{[1
]}

Challenger, CE ^{[1
]}

Closier, M ^{[1
]}

Evans, TJ ^{[1
]}

Lewis, ML ^{[1
]}

Mathias, JP ^{[1
]}

Nichols, CL ^{[1
]}

Po-Ba, YM ^{[1
]}

Snow, H ^{[1
]}

Stefaniak, MH ^{[1
]}

Vuong, HV ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Dept Discovery Chem, Sandwich CT13 9NJ, Kent, England

来源：

HETEROCYCLES | 2006年 / 67卷 / 02期

关键词：

aromatic substitution; cross coupling; pyrazole; thiazole; cyclization;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two routes to prepare a series of six 5-heterocyclic substituted 2-chloro-7-methoxyquinazolin-4-ones are described, where the heterocycle is a substituted or unsubstituted 1-pyrazolyl, 5-pyrazolyl or 2-thiazolyl group. Both routes proceeded via key 2-aminobenzonitrile intennediates.

引用

页码：489 / +

页数：7

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