A Preliminary Study Comparing Methadone and Buprenorphine in Patients with Chronic Pain and Coexistent Opioid Addiction

被引：67
|
作者：
Neumann, Anne M. [1 ]
Blondell, Richard D. [1 ]
Jaanimaegi, Urmo [1 ]
Giambrone, Amanda K. [2 ]
Homish, Gregory G. [3 ]
Lozano, Jacqueline R. [4 ]
Kowalik, Urszula [4 ]
Azadfard, Mohammadreza [1 ]
机构：
[1] SUNY Buffalo, Primary Care Res Inst, Dept Family Med, Buffalo, NY 14260 USA
[2] SUNY Buffalo, Dept Biostat, Buffalo, NY 14260 USA
[3] SUNY Buffalo, Dept Community Hlth & Hlth Behav, Buffalo, NY 14260 USA
[4] SUNY Buffalo, Sch Med, Buffalo, NY 14260 USA
来源：
JOURNAL OF ADDICTIVE DISEASES | 2013年 / 32卷 / 01期
关键词：
Opioid addiction; chronic pain; buprenorphine; methadone; opioids; CHRONIC NONMALIGNANT PAIN; SUBSTANCE-ABUSE; BACK-PAIN; DEPENDENCE; MAINTENANCE; MANAGEMENT;
D O I：
10.1080/10550887.2012.759872
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Patients with opioid addiction who receive prescription opioids for treatment of nonmalignant chronic pain present a therapeutic challenge. Fifty-four participants with chronic pain and opioid addiction were randomized to receive methadone or buprenorphine/naloxone. At the 6-month follow-up examination, 26 (48.1%) participants who remained in the study noted a 12.75% reduction in pain (P = 0.043), and no participants in the methadone group compared to 5 in the buprenorphine group reported illicit opioid use (P = 0.039). Other differences between the two conditions were not found. Long-term, low-dose methadone or buprenorphine/naloxone treatment produced analgesia in participants with chronic pain and opioid addiction.
引用
收藏
页码：68 / 78
页数：11
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