A Preliminary Study Comparing Methadone and Buprenorphine in Patients with Chronic Pain and Coexistent Opioid Addiction

被引：67

作者：

Neumann, Anne M. ^{[1
]}

Blondell, Richard D. ^{[1
]}

Jaanimaegi, Urmo ^{[1
]}

Giambrone, Amanda K. ^{[2
]}

Homish, Gregory G. ^{[3
]}

Lozano, Jacqueline R. ^{[4
]}

Kowalik, Urszula ^{[4
]}

Azadfard, Mohammadreza ^{[1
]}

机构：

[1] SUNY Buffalo, Primary Care Res Inst, Dept Family Med, Buffalo, NY 14260 USA

[2] SUNY Buffalo, Dept Biostat, Buffalo, NY 14260 USA

[3] SUNY Buffalo, Dept Community Hlth & Hlth Behav, Buffalo, NY 14260 USA

[4] SUNY Buffalo, Sch Med, Buffalo, NY 14260 USA

来源：

JOURNAL OF ADDICTIVE DISEASES | 2013年 / 32卷 / 01期

关键词：

Opioid addiction; chronic pain; buprenorphine; methadone; opioids; CHRONIC NONMALIGNANT PAIN; SUBSTANCE-ABUSE; BACK-PAIN; DEPENDENCE; MAINTENANCE; MANAGEMENT;

D O I：

10.1080/10550887.2012.759872

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Patients with opioid addiction who receive prescription opioids for treatment of nonmalignant chronic pain present a therapeutic challenge. Fifty-four participants with chronic pain and opioid addiction were randomized to receive methadone or buprenorphine/naloxone. At the 6-month follow-up examination, 26 (48.1%) participants who remained in the study noted a 12.75% reduction in pain (P = 0.043), and no participants in the methadone group compared to 5 in the buprenorphine group reported illicit opioid use (P = 0.039). Other differences between the two conditions were not found. Long-term, low-dose methadone or buprenorphine/naloxone treatment produced analgesia in participants with chronic pain and opioid addiction.

引用

页码：68 / 78

页数：11

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