Head in the WNT - the molecular nature of Spemann's head organizer

被引：159
|
作者：
Niehrs, C [1 ]
机构：
[1] Deutsch Krebsforschungszentrum, Div Mol Embryol, D-69120 Heidelberg, Germany
来源：
TRENDS IN GENETICS | 1999年 / 15卷 / 08期
关键词：
D O I：
10.1016/S0168-9525(99)01767-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Formation of the head during vertebrate embryogenesis has been one of the most-studied topics in development, probably because we are such cephalized beings ourselves. Early experimenters found that the head is induced during gastrulation by Spemann's organizer. In 1999 we celebrate the 75th anniversary of the discovery of the organizer by Spemann and Mangold, a group of cells in amphibia that secretes powerful signalling molecules. Recently, advances have been made in identifying candidate head inducers. Not surprisingly, these inducers act in familiar molecular pathways, namely transforming growth factor beta (TGF-beta) and WNT signalling.
引用
收藏
页码：314 / 319
页数：6
相关论文
共 50 条
  • [41] The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra
    Ziegler, Berenice
    Yiallouros, Irene
    Trageser, Benjamin
    Kumar, Sumit
    Mercker, Moritz
    Kling, Svenja
    Fath, Maike
    Warnken, Uwe
    Schnoelzer, Martina
    Holstein, Thomas W.
    Hartl, Markus
    Marciniak-Czochra, Anna
    Stetefeld, Jorg
    Stoecker, Walter
    Oezbek, Suat
    BMC BIOLOGY, 2021, 19 (01)
  • [42] The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra
    Berenice Ziegler
    Irene Yiallouros
    Benjamin Trageser
    Sumit Kumar
    Moritz Mercker
    Svenja Kling
    Maike Fath
    Uwe Warnken
    Martina Schnölzer
    Thomas W. Holstein
    Markus Hartl
    Anna Marciniak-Czochra
    Jörg Stetefeld
    Walter Stöcker
    Suat Özbek
    BMC Biology, 19
  • [43] NUCLEOLAR ORGANIZER REGIONS IN PARAGANGLIOMAS OF THE HEAD AND NECK
    GEE, MS
    KLIEWER, KE
    HINTON, DR
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 1992, 118 (04) : 380 - 383
  • [44] Vitalism, Holism, and Metaphorical Dynamics of Hans Spemann's "Organizer" in the Interwar Period
    Brandt, Christina
    JOURNAL OF THE HISTORY OF BIOLOGY, 2022, 55 (02) : 285 - 320
  • [45] Ethanol exposure affects Spemann's organizer through retinoic acid signaling
    Yelin, R
    Frumkin, A
    Kot, H
    Pillemer, G
    Fainsod, A
    DEVELOPMENTAL BIOLOGY, 2003, 259 (02) : 483 - 484
  • [46] The competence to establish Spemann's organizer is actively restricted in space and time.
    Levy, V
    Marom, K
    Zins, S
    Koutsia, N
    Yelin, R
    Fainsod, A
    DEVELOPMENTAL BIOLOGY, 2001, 235 (01) : 278 - 278
  • [47] Vitalism, Holism, and Metaphorical Dynamics of Hans Spemann’s “Organizer” in the Interwar Period
    Christina Brandt
    Journal of the History of Biology, 2022, 55 : 285 - 320
  • [48] The FGFR pathway is required for the trunk-inducing functions of Spemann's organizer
    Mitchell, TS
    Sheets, MD
    DEVELOPMENTAL BIOLOGY, 2001, 237 (02) : 295 - 305
  • [49] The molecular nature of the zebrafish tail organizer
    Antoine Agathon
    Christine Thisse
    Bernard Thisse
    Nature, 2003, 424 : 448 - 452
  • [50] Spemann organizer transcriptome induction by early beta-catenin, Wnt, Nodal, and Siamois signals in Xenopus laevis
    Ding, Yi
    Ploper, Diego
    Sosa, Eric A.
    Colozza, Gabriele
    Moriyama, Yuki
    Beniteza, Maria D. J.
    Zhang, Kelvin
    Merkurjev, Daria
    De Robertis, Edward M.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (15) : E3081 - E3090
12345