Comparison of MRI features and surgical outcome among the subtypes of focal cortical dysplasia

被引:34
|
作者
Kim, Dong Wook [2 ]
Kim, Sunghun [3 ]
Park, Sung-Hye [4 ]
Chung, Chun-Kee [5 ]
Lee, Sang Kun [1 ]
机构
[1] Seoul Natl Univ Hosp, Dept Neurol, Coll Med, Seoul 110744, South Korea
[2] Konkuk Univ, Dept Neurol, Sch Med, Seoul, South Korea
[3] Kwangwon Natl Univ, Dept Neurol, Coll Med, Chuncheon Si, South Korea
[4] Seoul Natl Univ Hosp, Dept Pathol, Coll Med, Seoul 110744, South Korea
[5] Seoul Natl Univ Hosp, Dept Neurosurg, Coll Med, Seoul 110744, South Korea
来源
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2012年 / 21卷 / 10期
基金
新加坡国家研究基金会;
关键词
Epilepsy surgery; Focal cortical dysplasia; MRI; TEMPORAL-LOBE EPILEPSY; HIPPOCAMPAL SCLEROSIS; NEOCORTICAL EPILEPSY; PROGNOSTIC-FACTORS; SEIZURE CONTROL; PATHOLOGY; SURGERY; INJURY; ABNORMALITIES; EEG;
D O I
10.1016/j.seizure.2012.09.006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: Focal cortical dysplasia (FCD) is the most common pathological diagnosis in patients who have undergone surgical treatment for intractable neocortical epilepsy. However, presurgical identification of MRI abnormalities in FCD patients remains difficult, and there are no highly sensitive imaging parameters available that can reliably differentiate among FCD subtypes. The purpose of our study was to investigate the surgical outcome in FCD patients with identifiable MRI abnormalities and to evaluate the prognostic role of the various MRI features and the characteristics of FCD pathology. Methods: We retrospectively recruited epilepsy patients who had undergone surgical treatment for refractory epilepsy with focal MRI abnormalities and the pathological diagnosis of FCD. We evaluated the surgical outcome according to the pathological subtypes, and studied the prognostic roles of various MRI features. We used recently proposed three-tiered FCD classification system which included FCD type III when FCD occurs in association with other potentially epileptogenic pathologies. Results: A total of 69 patients were included, and 68.1% of patients became seizure free. Patients with FCD type III had a lower chance for achieving seizure freedom (7/15) than in patients with isolated FCD (FCD types I and 11)(40/54, p = 0.044). Cortical thickness and blurring of gray-white matter junction were more common in isolated FCD than in FCD type III, but most MRI features failed to differentiate between FCD types I and II, and only the transmantle sign was specific for FCD type II. We failed to find a prognostic value of specific MRI abnormalities of prognostic value in terms of post-epilepsy surgery outcome in FCD patients. Conclusions: Our study showed that patients with FCD III have poor surgical outcome. Typical MRI features of isolated FCD such as cortical thickness and blurring of gray-white matter junction were less common in FCD type HI and only transmantle sign was helpful in differentiating between FCD types I and II. (C) 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:789 / 794
页数:6
相关论文
共 50 条
  • [31] Clinical characteristics, pathological features and surgical outcomes of focal cortical dysplasia (FCD) type II: correlation with pathological subtypes
    Yao, Kun
    Mei, Xi
    Liu, Xingzhou
    Duan, Zejun
    Liu, Changqing
    Bian, Yu
    Ma, Zhong
    Qi, Xueling
    NEUROLOGICAL SCIENCES, 2014, 35 (10) : 1519 - 1526
  • [32] Surgical management of Focal cortical dysplasia
    Mostofi, Keyvan
    Marnet, Dominique
    Derambure, Philippe
    ACTA NEUROLOGICA BELGICA, 2011, 111 (04) : 310 - 316
  • [33] FOCAL CORTICAL DYSPLASIA TYPE IIB: POSTOPERATIVE OUTCOME IN RELATION TO MRI MORPHOLOGY
    Wagner, Jan
    Urbach, H.
    Niehusmann, P.
    Elger, C. E.
    Wellmer, J.
    EPILEPSIA, 2009, 50 : 450 - 450
  • [34] A longitudinal study of surgical outcome of pharmacoresistant epilepsy caused by focal cortical dysplasia
    Bo Jin
    Jing Wang
    Jian Zhou
    Shuang Wang
    Yuguang Guan
    Shuhua Chen
    Journal of Neurology, 2016, 263 : 2403 - 2410
  • [35] Focal cortical dysplasia: long term seizure outcome after surgical treatment
    Kral, T.
    von Lehe, M.
    Podlogar, M.
    Clusmann, H.
    Sussmann, P.
    Kurthen, M.
    Becker, A.
    Urbach, H.
    Schramm, J.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2007, 78 (08): : 853 - 856
  • [36] A longitudinal study of surgical outcome of pharmacoresistant epilepsy caused by focal cortical dysplasia
    Jin, Bo
    Wang, Jing
    Zhou, Jian
    Wang, Shuang
    Guan, Yuguang
    Chen, Shuhua
    JOURNAL OF NEUROLOGY, 2016, 263 (12) : 2403 - 2410
  • [37] LONG-TERM SURGICAL OUTCOME IN PEDIATRIC PATIENTS WITH FOCAL CORTICAL DYSPLASIA
    Lizana, E. Martinez
    Fauser, S.
    Brandt, A.
    Jacobs, J.
    Schulze-Bonhage, A.
    EPILEPSIA, 2017, 58 : S32 - S32
  • [38] Electromagnetic source imaging predicts surgical outcome in children with focal cortical dysplasia
    Chikara, Rupesh Kumar
    Jahromi, Saeed
    Tamilia, Eleonora
    Madsen, Joseph R.
    Stufflebeam, Steve M.
    Pearl, Phillip L.
    Papadelis, Christos
    CLINICAL NEUROPHYSIOLOGY, 2023, 153 : 88 - 101
  • [39] Quantitative MRI profiling of focal cortical dysplasia
    Colliot, O
    Antel, SB
    Bernasconi, N
    Bernasconi, A
    EPILEPSIA, 2004, 45 : 286 - 287
  • [40] Focal transmantle cortical dysplasia: A particular MRI-based diagnostic type of focal cortical, dysplasia
    Kauffman, MA
    Consalvo, DE
    Oddo, SA
    Giagante, B
    Silva, WH
    Salgado, PA
    Sica, RE
    Kochen, SS
    EPILEPSIA, 2004, 45 : 112 - 112