Hydrothermal synthesis of nitrogen-doped carbon dots with real-time live-cell imaging and blood-brain barrier penetration capabilities

被引：99
|
作者：
Lu, Shousi [1 ,2 ]
Guo, Shanshan [1 ]
Xu, Pingxiang [1 ]
Li, Xiaorong [1 ]
Zhao, Yuming [1 ]
Gu, Wei [3 ]
Xue, Ming [1 ]
机构：
[1] Capital Med Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing Lab Biomed Detect Technol & Instrument, 10 Youanmenwaixitoutiao, Beijing 100069, Peoples R China
[2] Capital Med Univ, China Rehabil Res Ctr, Beijing, Peoples R China
[3] Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Chem & Biol, Beijing, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2016年 / 11卷
基金：
北京市自然科学基金;
关键词：
hydrothermal synthesis; nitrogen-doped carbon dots; bioimaging; NANOCOMPOSITE; NANOPARTICLES; FLUORESCENCE; MODEL; ACID;
D O I：
10.2147/IJN.S119252
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Nitrogen-doped carbon dots (N-CDs) were synthesized using a one-pot hydrothermal treatment with citric acid in the presence of polyethylenimine. Transmission electron microscopy analysis revealed that the N-CDs were monodispersed and quasi-spherical with an average size of similar to 2.6 nm. Under ultraviolet irradiation the N-CDs emitted a strong blue luminescence with a quantum yield as high as 51%. Moreover, the N-CDs exhibited a negligible cytotoxicity and could be applied as efficient nanoprobes for real-time imaging of live cells. In addition, the ability of the N-CDs to cross the blood-brain barrier (BBB) in a concentration-dependent manner was demonstrated using an in vitro BBB model. Therefore, these PEI-passivated N-CDs with real-time live-cell imaging and BBB-penetration capabilities hold promise for traceable drug delivery to the brain.
引用
收藏
页码：6325 / 6336
页数：12
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