TBHP/NH4I-Mediated Direct N-H Phosphorylation of Imines and Imidates

被引：19

作者：

Wang, Xiaofeng ^{[1
]}

Ou, Yingcong ^{[1
]}

Peng, Zhenbo ^{[2
]}

Yu, Guodian ^{[1
]}

Huang, Yuanting ^{[1
]}

Li, Xianwei ^{[1
]}

Huo, Yanping ^{[1
]}

Chen, Qian ^{[1
,3
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China

[2] Ningbo Polytech, Chem Engn Coll, Ningbo 315800, Zhejiang, Peoples R China

[3] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 22期

关键词：

DEHYDROGENATIVE COUPLING REACTION; PHOSPHINIC AMIDES; ASYMMETRIC-SYNTHESIS; EFFICIENT; BONDS; FUNCTIONALIZATION; SULFONYLATION; PHOSPHONATES; AMINES; THIOLS;

D O I：

10.1021/acs.joc.9b02301

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct and practical metal-free N-H phosphorylation has been achieved via the TBHP/NH4-Imediated cross-dehydrogenative coupling (CDC) reactions between imines/imidates and P(O)H compounds. This transformation provides an efficient synthetic route to the construction of P-N bonds with good functional group compatibility, leading to the formation of N-phosphorylimines and N-phosphorylimidates in up to 95% yield (33 examples) under mild conditions.

引用

页码：14949 / 14956

页数：8

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