Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19

被引:0
|
作者
Garbers, Christoph [1 ]
Rose-John, Stefan [2 ]
机构
[1] Otto von Guericke Univ, Dept Pathol, Med Fac, Magdeburg, Germany
[2] Univ Kiel, Inst Biochem, Kiel, Germany
来源
LANCET RHEUMATOLOGY | 2021年 / 3卷 / 02期
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E96 / E97
页数:2
相关论文
共 50 条
  • [31] Immunoadhesins of interleukin-6 and the IL-6 soluble IL-6R fusion protein hyper-IL-6
    Jostock, T
    Blinn, G
    Renné, C
    Kallen, KJ
    Rose-John, S
    Müllberg, J
    JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 223 (02) : 171 - 183
  • [32] Antitumor effects of interleukin-6 (IL-6)/interleukin-6 receptor (IL-6R) signaling pathway inhibition in clear cell carcinoma of the ovary
    Yanaihara, Nozomu
    Hirata, Yukihiro
    Yamaguchi, Noriko
    Noguchi, Yukiko
    Saito, Misato
    Nagata, Chie
    Takakura, Satoshi
    Yamada, Kyosuke
    Okamoto, Aikou
    MOLECULAR CARCINOGENESIS, 2016, 55 (05) : 832 - 841
  • [33] Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer
    Heo, Tae-Hwe
    Wahler, Joseph
    Suh, Nanjoo
    ONCOTARGET, 2016, 7 (13) : 15460 - 15473
  • [34] Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer
    Bharti, R.
    Dey, G.
    Ojha, P. K.
    Rajput, S.
    Jaganathan, S. K.
    Sen, R.
    Mandal, M.
    ONCOGENE, 2016, 35 (30) : 3965 - 3975
  • [35] IL-6R BLOCKADE ATTENUATES EXPERIMENTAL ALLERGIC ASTHMA ASSOCIATED WITH ACTIVATION OF THE IL-6 TRANS-SIGNALLING PATHWAY
    Ullah, Ashik M.
    Pharm, M.
    Revez, J.
    Loh, Z.
    Simpson, J.
    Zhang, V
    Bain, L.
    Varelias, A.
    Rose-John, S.
    Blumenthal, A.
    Smyth, M.
    Hill, G.
    Sukkar, M.
    Ferreira, M.
    Phipps, S.
    RESPIROLOGY, 2015, 20 : 32 - 32
  • [36] A Shift Towards Trans-Signalling Explains Relatively Low CRP Despite an Active Interleukin-6 (IL-6)/IL-6-Receptor (IL-6R) System in SLE
    Skwarek, Martyna
    Heschel, Babett
    Fantana, Julia
    Aringer, Martin
    ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S716 - S716
  • [37] IL-6R blockade attenuates experimental allergic asthma associated with activation of the IL-6 trans-signalling pathway
    Ullah, M. A.
    Revez, J.
    Loh, Z.
    Simpson, J.
    Zhang, V
    Bain, L.
    Varelias, A.
    Rose-John, S.
    Blumenthal, A.
    Smyth, M.
    Hill, G.
    Sukkar, M.
    Ferreira, M. A.
    Phipps, S.
    ALLERGY, 2015, 70 : 43 - 44
  • [38] IL-6/IL-6R系统与重组IL-6-PE40融合蛋白
    奚永志
    中国病理生理杂志, 1998, (04) : 98 - 102
  • [39] Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer
    R Bharti
    G Dey
    P K Ojha
    S Rajput
    S K Jaganathan
    R Sen
    M Mandal
    Oncogene, 2016, 35 : 3965 - 3975
  • [40] IL-6 Receptor Inhibitors in COVID-19: Efficacy on the Test Bench
    Wagner, Annkatrin
    TRANSFUSIONSMEDIZIN, 2021, 11 (03) : 151 - 151