A novel NIR fluorescent probe with ratiometric imaging of cysteine in endoplasmic reticulum

被引：2

作者：

Wang, Ziming ^{[1
]}

He, Shenwei ^{[1
]}

Xu, Xiujuan ^{[1
]}

Xie, Peiyao ^{[1
]}

Yan, Hanlei ^{[1
]}

Zhang, Di ^{[2
]}

Ye, Yong ^{[1
]}

Zhao, Yufen ^{[1
,3
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China

[2] Henan Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Zhengzhou 450002, Peoples R China

[3] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2022年 / 46卷 / 46期

关键词：

STRESS;

D O I：

10.1039/d2nj04902c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As a significant organelle in cells, endoplasmic reticulum is a cystic, vesicular and tubular structure formed by a single unit membrane. Herein, we develop an endoplasmic reticulum (ER)-targeting NIR probe, HL-Cys, for Cys, which has ratiometrically fluctuating UV-vis absorption and fluorescence spectra with large Stokes shift, with desirable selectivity and sensitivity. Biological imaging demonstrates that HL-Cys could locate in the ER and image Cys levels during ER oxidative stress in HeLa cells.

引用

页码：22000 / 22003

页数：4

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