Multi-trait analysis for genome-wide association study of five psychiatric disorders

被引：125

作者：

Wu, Yulu ^{[1
,2
,3
]}

Cao, Hongbao ^{[4
]}

Baranova, Ancha ^{[5
,6
]}

Huang, Hailiang ^{[7
,8
]}

Li, Sheng ^{[9
]}

Cai, Lei ^{[9
]}

Rao, Shuquan ^{[10
]}

Dai, Minhan ^{[1
,2
,3
]}

Xie, Min ^{[1
,2
,3
]}

Dou, Yikai ^{[1
,2
,3
]}

Hao, Qinjian ^{[11
]}

Zhu, Ling ^{[1
,2
,3
]}

Zhang, Xiangrong ^{[12
]}

Yao, Yin ^{[13
]}

Xu, Mingqing ^{[9
,14
]}

Wang, Qiang ^{[1
,2
,3
]}

Zhang, Fuquan ^{[15
]}

机构：

[1] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Psychiat Lab, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, West China Brain Res Ctr, Chengdu, Sichuan, Peoples R China

[4] Shanxi Med Univ, Hosp 1, Clin Med Coll 1, Dept Psychiat, Taiyuan, Peoples R China

[5] George Mason Univ, Sch Syst Biol, Fairfax, VA 22030 USA

[6] Res Ctr Med Genet, Moscow, Russia

[7] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA

[8] Broad Inst Harvard & MIT, Stanley Ctr Psychiat Res, Cambridge, MA USA

[9] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, 1954 Huashan Rd, Shanghai 200030, Peoples R China

[10] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu, Peoples R China

[11] Sichuan Univ, Ctr Gerontol & Geriatr, West China Hosp, Chengdu, Sichuan, Peoples R China

[12] Nanjing Med Univ, Nanjing Brain Hosp, Dept Geriatr Psychiat, Nanjing, Peoples R China

[13] Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China

[14] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, 600 South Wanping Rd, Shanghai 200030, Peoples R China

[15] Nanjing Med Univ, Affiliated Brain Hosp, Dept Psychiat, 264 Guangzhou Rd, Nanjing, Peoples R China

来源：

TRANSLATIONAL PSYCHIATRY | 2020年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

EXPRESSION; SCHIZOPHRENIA; HERITABILITY; SORCS3; RISK;

D O I：

10.1038/s41398-020-00902-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) (n = 65,967), bipolar disorder (BD) (n = 41,653), autism spectrum disorder (ASD) (n = 46,350), attention deficit hyperactivity disorder (ADHD) (n = 55,374), and depression (DEP) (n = 688,809). After the meta-analysis, the number of genomic loci increased from 14 to 19 in ADHD, from 3 to 10 in ASD, from 45 to 57 in DEP, from 8 to 54 in BD, and from 64 to 87 in SCZ. We observed significant enrichment of overlapping genes among different disorders and identified a panel of cross-disorder genes. A total of seven genes were found being commonly associated with four out of five psychiatric conditions, namelyGABBR1,GLT8D1,HIST1H1B,HIST1H2BN,HIST1H4L,KCNB1, andDCC. The SORCS3 gene was highlighted due to the fact that it was involved in all the five conditions of study. Analysis of correlations unveiled the existence of two clusters of related psychiatric conditions, SCZ and BD that were separate from the other three traits, and formed another group. Our results may provide a new insight for genetic basis of the five psychiatric disorders.

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页数：11

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