Comparison of Outcomes Between Single-level Lateral Lumbar Interbody Fusion and Transforaminal Lumbar Interbody Fusion A Meta-analysis and Systematic Review

Study Design: This is a meta-analysis and systematic review of the available literature. Objective: This study aims to compare the clinical and radiologic outcomes of single-level lateral lumbar interbody fusion (LLIF) with single-level transforaminal lumbar interbody fusion (TLIF). Summary of Background Data: In the treatment of adult spinal deformity, LLIF allows interbody fusion while avoiding complications associated with an anterior or transforaminal approach, although the clinical outcomes of LLIF compared with other approaches have not been well established. Methods: We searched PubMed, Embase, and Scopus for 385 unique studies. On the basis of our exclusion criteria, 8 studies remained for our systematic review. Data were analyzed using Review Manager 5.3 using Mantel-Haenszel statistics and random effect models. This study identified self-reported Visual Analog Scale (VAS), Oswestry Disability Index, length of stay, blood loss, complication rate, and radiologic parameters (disk height, lumbar lordosis, segmental lordosis). Results: Our meta-analysis showed that LLIF contributed to decreased blood loss [mean difference (MD) = -67.62 mL, 95% confidence interval (CI): -104 to -30.90, P < 0.001], superior restoration of segmental lordosis (MD = 1.91 degrees, 95% CI: 0.71-3.10, P = 0.002), lumbar lordosis (MD =1.95 degrees, 95% CI: 0.15-3.74, P = 0.03), and disk height (MD = 2.18 mm, 95% CI: 1.18-3.17, P < 0.001) when compared with TLIF. However, current data suggests no significant difference in clinical outcomes between LLIF and TLIF based on overall complication rates (P = 0.22), length of hospital stay (P = 0.65), postoperative Oswestry Disability Index (P = 0.13), postoperative VAS Back Pain (P =0.47) and VAS Leg Pain (P =0.16). Conclusions: LLIF is an increasingly popular option for singlelevel anterior column reconstruction. When compared with single-level TLIF, single-level LLIF is associated with greater changes in lumbar lordosis and disk height. The single-level LLIF is a viable alternative to TLIF, demonstrating comparable clinical outcomes and better restoration of spinopelvic parameters.