Structural analysis of the epitope of the anti-HIV mAb 2F5 sheds light into its mechanism of neutralization and HIV fusion

被引：0
|
作者：
Pessi, A
Barbato, G
Ingallinella, P
Hurni, WH
Miller, MD
Ciliberto, G
Cortese, R
Bazzo, R
Shiver, JW
Bianchi, E
机构：
[1] IRBM, Merck Res Labs, I-00040 Rome, Italy
[2] Merck Res Labs, W Point, PA 19486 USA
来源：
BIOPOLYMERS | 2003年 / 71卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
O68
引用
收藏
页码：299 / 300
页数：2
相关论文
共 50 条
  • [31] Heterologous Epitope-Scaffold Prime:Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant
    Guenaga, Javier
    Dosenovic, Pia
    Ofek, Gilad
    Baker, David
    Schief, William R.
    Kwong, Peter D.
    Hedestam, Gunilla B. Karlsson
    Wyatt, Richard T.
    PLOS ONE, 2011, 6 (01):
  • [32] Kynureninase is the conserved self-antigen mimicked by the 2F5 Neutralizing Epitope of HIV-1 gp41
    Yang, Guang
    Holl, T.
    Liu, Yang
    Li, Yi
    Lu, Xiaozhi
    Nicely, Nathan
    Kepler, Thomas
    Alam, S.
    Liao, Hua-Xin
    Cain, Derek
    Spicer, Leonard
    VandeBerg, John
    Haynes, Barton
    Kelsoe, Garnett
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [33] Including peptides-mimotopes of neutralizing 2F5 epitope of HIV-1 into artificial peptide TBI - vaccine candidate
    Scherbakova, N. S.
    Chikaev, A.
    Tumanova, O.
    Karpenko, L.
    Il'ichev, A.
    RETROVIROLOGY, 2009, 6
  • [34] Structure-based discovery of small molecules improving stability of human broadly-neutralizing anti-HIV antibody 2F5 in plant suspension cells
    Mandal, Manoj K.
    Kronenberger, Thales
    Zulka, Marie, I
    Windshugel, Bjorn
    Schiermeyer, Andreas
    BIOTECHNOLOGY JOURNAL, 2022, 17 (04)
  • [35] Passive administration of the anti-HIV gp41-specific human monoclonal antibody 2F5 delays, but does not prevent, a primary HIV-1 isolate from establishing an infection in chimpanzees
    Conley, AJ
    Kessler, JA
    Boots, LJ
    McKenna, PM
    Schleif, WA
    Emini, EA
    Katinger, H
    Cobb, EK
    Lunceford, SM
    Rouse, SR
    Murthy, KK
    VACCINES 96 - MOLECULAR APPROACHES TO THE CONTROL OF INFECTIOUS DISEASES, 1996, : 299 - 303
  • [36] Characterization of an Anti-Idiotypic Antibody Blocking the Capacity of the HIV-1 Specific nMAb 2F5
    Gach, Johannes
    Steinfellner, Willibald
    Loschel, Martina
    Hahn, Rainer
    Quendler, Heribert
    Katinger, Hermann
    Kunert, Renate
    CELLS AND CULTURE, 2010, 4 : 803 - 806
  • [37] Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures
    Sack, Markus
    Paetz, Antje
    Kunert, Renate
    Bomble, Michael
    Hesse, Friedemann
    Stiegler, Gabriela
    Fischer, Rainer
    Katinger, Hermann
    Stoeger, Eva
    Rademacher, Thomas
    FASEB JOURNAL, 2007, 21 (08): : 1655 - 1664
  • [38] Molecular characterization of five neutralizing anti-HIV type 1 antibodies:: Identification of nonconventional D segments in the human monoclonal antibodies 2G12 and 2F5
    Kunert, R
    Rüker, F
    Katinger, H
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (13) : 1115 - 1128
  • [39] Analysis and dissociation of anti-HIV effects of shRNA to CCR5 and the fusion inhibitor C46
    Ledger, Scott
    Howe, Annett
    Turville, Stuart
    Aggarwal, Anupriya
    Savkovic, Borislav
    Ong, Andrew
    Wolstein, Orit
    Boyd, Maureen
    Millington, Michelle
    Gorry, Paul R.
    Murray, John M.
    Symonds, Geoff
    JOURNAL OF GENE MEDICINE, 2018, 20 (2-3):
  • [40] Partial humanization and characterization of an anti-idiotypic antibody against monoclonal antibody 2F5, a potential HIV vaccine?
    Gach, Johannes S.
    Quendler, Heribert
    Weik, Robert
    Katinger, Hermann
    Kunert, Renate
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (11) : 1405 - 1415
12345