Efficacy of liraglutide intervention in myocardial infarction A meta-analysis of randomized controlled trials

Introduction. The efficacy of liraglutide intervention for myocardial infarction (MI) remains controversial. We conducted a systematic review and meta-analysis to explore the influence of liraglutide intervention versus placebo on cardiac function for MI. Methods. We searched PubMed, Embase, Web of science, EBSCO, and Cochrane library databases through April 2018 for randomized controlled trials (RCTs) assessing the effect of liraglutide intervention versus placebo on MI. This meta-analysis was performed using the random-effect model. Results. Four randomized controlled trials involving 469 patients were included in the meta-analysis. Overall, compared with control group for MI, liraglutide intervention significantly improved left ventricular ejection fraction (mean difference [MD] = 4.42; 95% confidence interval [CI] =1.71 to 7.14;P = 0.001), superoxide dismutase (MD = 6.89; 95% CI = 1.80 to 11.98;P = 0.008), and decreased high-sensitivity C-reactive protein (MD = -0.21; 95% CI = -0.33 to -0.09;P = 0.0006), but had no remarkable influence on major adverse cardiovascular events (risk ratio = 0.56; 95% CI = 0.28-1.09;P = 0.09), recurrence of MI (risk ratio = 0.50; 95% CI = 0.19-1.30;P = 0.16), repeated revascularization (risk ratio = 0.49; 95% CI = 0.17-1.42;P = 0.19), and cardiac death (risk ratio = 0.57; 95% CI = 0.12-2.73;P = 0.48). Conclusions. Liraglutide intervention is associated with significantly improved left ventricular ejection fraction and superoxide dismutase, reduced high-sensitivity C-reactive protein in patients with MI, but has no remarkable impact on major adverse cardiovascular events, recurrence of MI, repeated revascularization or cardiac death.