Anti-carcinogenic activity of Taraxacum plant.: I

被引：0

作者：

Takasaki, M

Konoshima, T ^{[1
]}

Tokuda, H

Masuda, K

Arai, Y

Shiojima, K

Ageta, H

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan

[2] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6028041, Japan

[3] Showa Coll Pharmaceut Sci, Machida, Tokyo 1948543, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1999年 / 22卷 / 06期

关键词：

anti-carcinogenic activity; Taraxacum japonicum; anti-tumor-promoter; anti-tumor-initiator; (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-I); fumonisin B1;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An extract of the roots of Taraxacum japonicum (Compositae) exhibited strong anti-tumor-promoting activities on the two-stage carcinogenesis of mouse skin tumor induced by dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-3-acetate (TPA) as a promoter, as well as on that induced by DMBA and fumonisin B1. Further, the extract exhibited anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) as an initiator and TPA as a promoter. These results suggested that an extract of the roots of the Taraxacum plant could be a valuable chemopreventive agent against chemical carcinogenesis.

引用

页码：602 / 605

页数：4

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