Universal Anticancer Cu(DTC)2 Discriminates between Thiols and Zinc(II) Thiolates Oxidatively

被引：16
|
作者：
Xu, Luyan [1 ,4 ,5 ]
Xu, Jialin [1 ]
Zhu, Jingwei [3 ]
Yao, Zijian [3 ]
Yu, Na [1 ]
Deng, Wei [3 ]
Wang, Yu [2 ]
Lin, Bo-Lin [1 ,4 ,5 ]
机构：
[1] ShanghaiTech Univ, Sch Phys Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
[2] Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, Shanghai Adv Res Inst, 239 Zhangheng Rd, Shanghai 201204, Peoples R China
[3] Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China
[4] Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 18期
基金：
中国国家自然科学基金;
关键词：
anticancer; copper; redox chemistry; sulfides; zinc; COPPER; COORDINATION; SPECTROSCOPY; BIOCHEMISTRY; STRESS; CANCER;
D O I：
10.1002/anie.201814519
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aerobic organisms must rely on abundant intracellular thiols to reductively protect various vital functional units, especially ubiquitous zinc(II) thiolate sites of proteins, from deleterious oxidations resulting from oxidizing environments. Disclosed here is the first well-defined model study for reactions between zinc(II) thiolate complexes and copper(II) complexes. Among all the studied ligands of copper(II), diethyldithiocarbamate (DTC) displays a unique redox-tuning ability that enables copper(II) to resist the reduction by thiols while retaining its ability to oxidize zinc(II) thiolates to form disulfides. This work proves for the first time that it is possible to develop oxidants to discriminate between thiols and zinc(II) thiolates, alluding to a new chemical principle for how oxidants, especially universal anticancer Cu(DTC)(2), might circumvent the intracellular reductive defense around certain zinc(II) thiolate sites of proteins to kill malignant cells.
引用
收藏
页码：6070 / 6073
页数：4
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