Landscape of TSC1 and TSC2 mutations in patients with advanced solid cancers

被引:0
|
作者
Gulati, Gunsagar S. [1 ]
Cacheris, William [2 ]
Dutta, Ritika [1 ]
Ahnert, Jordi Rodon [3 ]
机构
[1] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
[2] Tessellon, Chesterfield, MO USA
[3] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5799
引用
收藏
页数:2
相关论文
共 50 条
  • [31] TSC1 and TSC2 gene mutations and their implications for treatment in Tuberous Sclerosis Complex: a review
    Rosset, Clevia
    Oliveira Netto, Cristina Brinckmann
    Ashton-Prolla, Patricia
    GENETICS AND MOLECULAR BIOLOGY, 2017, 40 (01) : 69 - 79
  • [32] Exonic Mutations of TSC2/TSC1 Are Common but Not Seen in All Sporadic Pulmonary Lymphangioleiomyomatosis
    Badri, Kameswara Rao
    Gao, Ling
    Hyjek, Elizabeth
    Schuger, Noa
    Schuger, Lucia
    Qin, Wei
    Chekaluk, Yvonne
    Kwiatkowski, David J.
    Zhe, Xiaoning
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (06) : 663 - 665
  • [33] A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles
    Pollizzi, Kristen
    Malinowska-Kolodziej, Izabela
    Doughty, Cheryl
    Betz, Charles
    Ma, Jian
    Goto, June
    Kwiatkowski, David J.
    HUMAN MOLECULAR GENETICS, 2009, 18 (13) : 2378 - 2387
  • [34] Institutional experience with nab-sirolimus in patients with malignancies harboring TSC1 or TSC2 mutations.
    Dickson, Mark Andrew
    Ravi, Vinod
    Ganjoo, Kristen N.
    Iyer, Gopa
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [35] Excess of TSC2 over TSC1 mutations in tuberous sclerosis and evidence for a phenotype difference
    Sampson, J
    Jones, A
    Maheshwar, M
    Thomas, M
    Idziaszczyk, S
    Krawczak, CJP
    EUROPEAN JOURNAL OF HUMAN GENETICS, 1998, 6 : 61 - 61
  • [36] Mutations in TSC1 and TSC2 Are Associated with High Tumor Mutational Burden and Therapeutic Options
    Gay, Laurie M.
    Elvin, Julia A.
    Suh, James
    Vergilio, Jo-Anne
    Ramkissoon, Shakti H.
    Schrock, Alexa
    Ali, Siraj M.
    Fabrizio, David
    Frampton, Garrett
    Millet, Vincent
    Stephens, Philip
    Ross, Jeffrey
    MODERN PATHOLOGY, 2017, 30 : 457A - 457A
  • [37] Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma
    Kwiatkowski, David J.
    Choueiri, Toni K.
    Fay, Andre P.
    Rini, Brian I.
    Thorner, Aaron R.
    de Velasco, Guillermo
    Tyburczy, Magdalena E.
    Hamieh, Lana
    Albiges, Laurence
    Agarwal, Neeraj
    Ho, Thai H.
    Song, Jiaxi
    Pignon, Jean-Christophe
    Barrios, Pablo M.
    Michaelson, M. Dror
    Van Allen, Eliezer M.
    Krajewski, Katherine M.
    Porta, Camillo
    Pal, Sumanta Kumar
    Bellmunt, Joaquim
    McDermott, David F.
    Heng, Daniel Y. C.
    Gray, Kathryn P.
    Signoretti, Sabina
    CLINICAL CANCER RESEARCH, 2016, 22 (10) : 2445 - 2452
  • [38] TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
    Chong-Kopera, H
    Inoki, K
    Li, Y
    Zhu, TQ
    Garcia-Gonzalo, FR
    Rosa, JL
    Guan, KL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (13) : 8313 - 8316
  • [39] Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis.
    Nijda, Y
    Lawrence-Smith, N
    Lewis, J
    Beauchamp, RL
    Sims, K
    Ramesh, V
    Ozelius, L
    AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) : A406 - A406
  • [40] TSC1 and TSC2 Gene Mutations in Chinese Tuberous Sclerosis Complex Patients Clinically Characterized by Epilepsy
    He, Jing
    Zhou, Wenjing
    Shi, Jie
    Lin, Jiuluan
    Zhang, Bingqing
    Sun, Zhaohui
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2020, 24 (01) : 1 - 5