BH3120: A novel bispecific antibody targeting 4-1BB and PD-L1 with well balanced efficacy and safety profiles.

被引：0
|
作者：
Xu, Jiangcheng [1 ]
Liu, Yang [1 ]
Wang, Jing [1 ]
Fan, Fei [1 ]
Gu, Haitao [1 ]
Zhang, Lanxin [1 ]
Wang, Jun [1 ]
Song, Ding [1 ]
Guo, Ailong [1 ]
Zhang, Hongjuan [1 ]
Su, Kaixuan [1 ]
Su, Jiaojiao [1 ]
Li, Lijuan [1 ]
Cai, Jingmei [1 ]
Zhang, Aihong [1 ]
Liu, Jiawang [1 ]
Lee, Kyoungwoo [1 ]
机构：
[1] Beijing Hanmi Res Ctr, Beijing, Peoples R China
来源：
CANCER RESEARCH | 2022年 / 82卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
5605
引用
收藏
页数：1
相关论文
共 50 条
  • [21] A COMPUTATIONAL SEMI-MECHANISTIC PHARMACOLOGY MODEL OF ATG101, A PD-L1/4-1BB BISPECIFIC ANTIBODY FOR TREATMENT OF SOLID TUMORS AND NHL
    Flowers, David
    Presler, Marc
    Subramanian, Kas
    Yuraszeck, Theresa
    Hui Yuwen
    Hou, Bing
    Hoenemann, Dirk
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A241 - A242
  • [22] A Novel Bispecific Antibody Targeting PD-L1 and VEGF With Combined Anti-Tumor Activities
    Cui, Xiaopei
    Jia, Huifeng
    Xin, Hong
    Zhang, Lei
    Chen, Shi
    Xia, Simin
    Li, Xue
    Xu, Wei
    Chen, Xiaofang
    Feng, Yujie
    Wei, Xiaoyue
    Yu, Haijia
    Wang, Yanting
    Zhan, Yifan
    Zhu, Xiangyang
    Zhang, Xuemei
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [23] Striking the Balance with a PD-L1x4-1BB Bispecific Antibody
    Ha, Jonghoon
    Grippin, Adam J.
    Kim, Betty Y. S.
    Jiang, Wen
    CANCER RESEARCH, 2024, 84 (10) : 1546 - 1547
  • [24] Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma
    Wang, Yichen
    Zhang, Xuyao
    Xu, Caili
    Nan, Yanyang
    Fan, Jiajun
    Zeng, Xian
    Kwon, Byoung S.
    Ju, Dianwen
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [25] Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity
    Rubio-Perez, Laura
    Frago, Susana
    Compte, Marta
    Navarro, Rocio
    Harwood, Seandean L.
    Lazaro-Gorines, Rodrigo
    Gomez-Rosel, Marina
    Hangiu, Oana
    Silva-Pilipich, Noelia
    Vanrell, Lucia
    Smerdou, Cristian
    Alvarez-Vallina, Luis
    ANTIBODIES, 2024, 13 (02)
  • [26] KEY PHARMACOKINETIC AND PHARMACODYNAMIC PARAMETERS THAT CORRELATE WITH THE ANTI-TUMOR ACTIVITY OF A BISPECIFIC PD-L1 CONDITIONAL 4-1BB AGONIST
    Kinkead, Heather
    Macedo, Chelsie
    Sanabria, Angelica
    Cyprus, Garrett
    Pandit, Rajay
    Kalabus, James
    Becklund, Bryan
    Sulzmaier, Florian
    Timmer, John
    Deveraux, Quinn
    Eckelman, Brendan
    Heidt, Analeah
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A12 - A12
  • [27] Radiolabelling and preclinical characterisation of [89Zr]Zr-Df-ATG-101 bispecific to PD-L1/4-1BB
    Cao, Zhipeng
    Wichmann, Christian Werner
    Burvenich, Ingrid Julienne Georgette
    Osellame, Laura Danielle
    Guo, Nancy
    Rigopoulos, Angela
    O'Keefe, Graeme Joseph
    Scott, Fiona Elizabeth
    Lorensuhewa, Nirmal
    Lynch, Kevin Patrick
    Scott, Andrew Mark
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2024, 51 (11) : 3202 - 3214
  • [28] Assessment of target-mediated biodistribution of an 89Zr labeled PD-L1/4-1BB bispecific Mabcalin protein
    van Winkel, Claudia A.
    Fan, Xiaoyu
    Giesen, Danique
    Gauderat, Glenn
    Pattarini, Lucia
    Jaquin, Thomas
    Barakat, Anissa
    De La Bigne, Anne-Marie
    Richter, Marleen
    Andersen, Nicole
    Legrand, Julie
    Lelievre, Helene
    de Vries, Elisabeth G.
    Morales-Kastresana, Aizea
    Lub-de Hooge, Marjolijn N.
    CANCER RESEARCH, 2023, 83 (07)
  • [29] A bispecific antibody targeting HER2 and PD-L1 inhibits tumor growth with superior efficacy
    Chen, Yi-Li
    Cui, Yue
    Liu, Xinyuan
    Liu, Guojian
    Dong, Xingchen
    Tang, Lei
    Hung, Yifeng
    Wang, Chunhe
    Feng, Mei-Qing
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 297 (06)
  • [30] Study of PRS-344/S095012 a PD-L1/4-1BB bispecific antibody-Anticalin®-fusion in patients with solid tumors.
    Jungels, Christiane
    Kotecki, Nuria
    Calvo, Emiliano
    Garralda, Elena
    Price, Timothy
    Zahn, Xiaojiang
    Abbas, Atif
    Mahnke, Lisa
    Rauschning, Winrich
    Morales-Kastresana, Aizea
    Pattarini, Lucia
    Bossenmaier, Birgit
    Scholer-Dahirel, Alix
    Demuth, Tim
    Legrande, Julie
    CANCER RESEARCH, 2022, 82 (12)
12345