Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward

被引：82

作者：

Hardaway, J. Andrew ^{[1
,2
,3
]}

Halladay, Lindsay R. ^{[14
,15
]}

Mazzone, Christopher M. ^{[1
,2
,6
]}

Pati, Dipanwita ^{[1
,2
]}

Bloodgood, Daniel W. ^{[1
,2
,6
]}

Kim, Michelle ^{[1
,2
]}

Jensen, Jennifer ^{[1
,2
]}

DiBerto, Jeffrey F. ^{[1
,2
]}

Boyt, Kristen M. ^{[1
,2
]}

Shiddapur, Ami ^{[1
,2
]}

Erfani, Ave ^{[1
,2
]}

Hon, Olivia J. ^{[1
,2
,6
]}

Neira, Sofia ^{[1
,2
,6
]}

Stanhope, Christina M. ^{[1
,2
]}

Sugam, Jonathan A. ^{[1
,2
]}

Saddoris, Michael P. ^{[7
]}

Tipton, Greg ^{[1
,2
]}

McElligott, Zoe ^{[1
,2
,3
]}

Jhou, Thomas C. ^{[13
]}

Stuber, Garret D. ^{[3
,4
]}

Bruchas, Michael R. ^{[9
,10
,11
,12
]}

Bulik, Cynthia M. ^{[3
,5
,8
]}

Holmes, Andrew ^{[14
]}

Kash, Thomas L. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Dept Pharmacol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Psychiat, Sch Med, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Dept Cell Biol & Physiol, Sch Med, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA

[6] Univ N Carolina, Neurobiol Curriculum, Chapel Hill, NC 27599 USA

[7] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA

[8] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[9] Washington Univ, Sch Med, Dept Anesthesiol, Div Basic Res, St Louis, MO 63110 USA

[10] Univ Washington, Ctr Neurobiol Addict Pain & Emot, Seattle, WA 98195 USA

[11] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA

[12] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

[13] Med Univ South Carolina, Dept Neurosci, Charleston, SC 29425 USA

[14] NIAAA, Lab Behav & Genom Neurosci, NIH, Bethesda, MD USA

[15] Santa Clara Univ, Dept Psychol, Santa Clara, CA 95053 USA

来源：

NEURON | 2019年 / 102卷 / 05期

基金：

瑞典研究理事会;

关键词：

CORTICOTROPIN-RELEASING-FACTOR; CENTRAL NUCLEUS; NEURAL CIRCUITS; MESSENGER-RNA; BED NUCLEUS; ORPHANIN FQ; SYSTEM; NEUROTENSIN; ACTIVATION; MORPHOLOGY;

D O I：

10.1016/j.neuron.2019.03.037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Food palatability is one of many factors that drives food consumption, and the hedonic drive to feed is a key contributor to obesity and binge eating. In this study, we identified a population of prepronociceptin-expressing cells in the central amygdala (Pnoc(CeA)) that are activated by palatable food consumption. Ablation or chemogenetic inhibition of these cells reduces palatable food consumption. Additionally, ablation of Pnoc(CeA) cells reduces high-fat-diet-driven increases in bodyweight and adiposity. Pnoc(CeA) neurons project to the ventral bed nucleus of the stria terminalis (vBNST), parabrachial nucleus (PBN), and nucleus of the solitary tract (NTS), and activation of cell bodies in the central amygdala (CeA) or axons in the vBNST, PBN, and NTS produces reward behavior but did not promote feeding of palatable food. These data suggest that the Pnoc(CeA) network is necessary for promoting the reinforcing and rewarding properties of palatable food, but activation of this network itself is not sufficient to promote feeding.

引用

页码：1037 / +

页数：23

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