Recent Advances in Synthetic Routes to Azacycles

被引:4
|
作者
Nguyen, Anh Thu [1 ]
Kim, Hee-Kwon [1 ,2 ]
机构
[1] Jeonbuk Natl Univ, Med Sch & Hosp, Dept Nucl Med, Jeonju 54907, South Korea
[2] Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Biomed Res Inst, Jeonju 54907, South Korea
来源
MOLECULES | 2023年 / 28卷 / 06期
基金
新加坡国家研究基金会;
关键词
azacycles; N-heterocycles; heterocyclic synthesis; ARYL-SUBSTITUTED AZACYCLES; AQUEOUS N-HETEROCYCLIZATION; ELECTRONIC-STRUCTURE; MEDIATED SYNTHESIS; AZOMETHINE YLIDES; 3+2 CYCLOADDITION; PRIMARY AMINES; AMINATION; CYCLIZATION; INHIBITORS;
D O I
10.3390/molecules28062737
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A heterocycle is an important structural scaffold of many organic compounds found in pharmaceuticals, materials, agrochemicals, and biological processes. Azacycles are one of the most common motifs of a heterocycle and have a variety of applications, including in pharmaceuticals. Therefore, azacycles have received significant attention from scientists and a variety of methods of synthesizing azacycles have been developed because their efficient synthesis plays a vital role in the production of many useful compounds. In this review, we summarize recent approaches to preparing azacycles via different methods as well as describe plausible reaction mechanisms.
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页数:44
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