Catalyst-Free Synthesis of Polycyclic Spiroindolines by Cascade Reaction of 3-(2-Isocyanoethyl)indoles with 1-Sulfonyl-1,2,3-triazoles

被引：4

作者：

Chen, Cong ^{[1
]}

Chen, Jing ^{[1
]}

Wang, Han ^{[1
]}

Xu, Ze-Feng ^{[1
]}

Duan, Shengguo ^{[1
]}

Li, Chuan-Ying ^{[1
]}

机构：

[1] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Key Lab Surface & Interface Sci Polymer Mat Zhejia, Hangzhou 310018, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 13期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC TOTAL SYNTHESES; NATURAL-PRODUCTS; DIASTEREOSELECTIVE SYNTHESIS; ALKALOIDS; CONSTRUCTION; STRYCHNOS; FUNCTIONALIZATION; CYCLOPROPANATION; VINBLASTINE; PYRROLES;

D O I：

10.1021/acs.joc.3c00800

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalyst-free cascade reaction of 3-(2-isocyanoethyl)indolesand 1-sulfonyl-1,2,3-triazoles was realized. This dearomative spirocyclizationprovided an efficient protocol to synthesize a series of polycyclicindolines bearing spiro-alpha-carboline in moderate to high yieldsin one step under thermal reaction conditions.

引用

页码：9543 / 9553

页数：11

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