PHARMACOKINETICS, PHARMACODYNAMICS, AND SAFETY RESULTS FROM A PHASE 1 MULTIPLE ASCENDING DOSE STUDY OF THE SELECTIVE ALDOSTERONE SYNTHASE INHIBITOR CIN-107

被引：0
|
作者：
Freeman, Mason W. [1 ]
Bond, Mary [2 ]
Murphy, Brian [2 ]
Hui, James [1 ]
Isaacson, Jonathan [2 ]
机构：
[1] CinCor Pharma Inc, Boston, MA USA
[2] CinRx Pharma LLC, Cincinnati, OH USA
来源：
JOURNAL OF HYPERTENSION | 2023年 / 41卷
关键词：
D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
S-16-4
引用
收藏
页码：E42 / E43
页数：2
相关论文
共 50 条
  • [31] MIV-711, a Highly Selective Cathepsin K Inhibitor, First in Man Study - Safety, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Oral Doses in Healthy Subjects
    Grabowska, Urszula
    Jerling, Markus
    Bottiger, Disa
    Larsson, Torbjorn
    Danielson, Kerstin
    Lindstrom, Erik
    Edenius, Charlotte
    JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28
  • [32] Safety, pharmacokinetics, and pharmacodynamics of ascending multiple oral doses of a new protease activated receptor-1 inhibitor in healthy volunteers
    Marion, A.
    Reyes, J.
    Chen, H.
    Wittek, A.
    JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 46 (09): : 1085 - 1085
  • [33] A phase 1 single ascending dose study of the safety, tolerability and pharmacokinetics of CRV431
    Armas, Danielle
    Snyder, Michael
    Trepanier, Daniel
    Ure, Daren
    Greytok, Jill
    Foster, Robert
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E464 - E465
  • [34] A phase 1 multiple ascending dose study to investigate the safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of KD033 in subjects with metastatic or locally advanced solid tumors.
    Luke, Jason J.
    Olszanski, Anthony J.
    Puzanov, Igor
    Lu, Dan
    Hackett, Adrian
    Martomo, Stella
    Patel, Jeegar
    Schueller, Olivier
    Mora, Alessandro
    Schlitt, Miranda L.
    Li, Linghui
    CANCER RESEARCH, 2021, 81 (13)
  • [35] A PHASE 1, SINGLE AND MULTIPLE ASCENDING DOSE STUDY OF SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF AG-519, AN ALLOSTERIC ACTIVATOR OF PYRUVATE KINASE-R IN HEALTHY SUBJECTS
    Barbier, A.
    Cutie, J.
    Connor, G.
    Merica, E.
    Kung, C.
    Le, K.
    Yang, H.
    Kosinski, P. A.
    Silverman, L.
    Yuan, Z. J.
    Agresta, S.
    Cohen, M.
    HAEMATOLOGICA, 2016, 101 : 301 - 301
  • [36] Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects
    Spencer I. Danto
    Negin Shojaee
    Ravi Shankar P. Singh
    Cheryl Li
    Steven A. Gilbert
    Zorayr Manukyan
    Iain Kilty
    Arthritis Research & Therapy, 21
  • [37] Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects
    Danto, Spencer, I
    Shojaee, Negin
    Singh, Ravi Shankar P.
    Li, Cheryl
    Gilbert, Steven A.
    Manukyan, Zorayr
    Kilty, Iain
    ARTHRITIS RESEARCH & THERAPY, 2019, 21 (01)
  • [38] The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses
    Yang, Yuanxun
    Yu, Lei
    Sheng, Zejuan
    Lin, Hui
    Weng, Zuyi
    Song, Wei
    Cao, Bei
    Zhao, Yu
    Gao, Yingsheng
    Ni, Shumao
    Wang, Huimin
    Ma, Tingting
    Huang, Lei
    Sun, Caixia
    Li, Juan
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [39] Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study
    Xu, Hongrong
    Sheng, Lei
    Chen, Weili
    Yuan, Fei
    Yang, Mengjie
    Li, Hui
    Li, Xuening
    Choi, John
    Zhao, Guiyu
    Hu, Tianxin
    Li, Yongguo
    Zhang, Yi
    Chen, Li
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 10 : 1619 - 1626
  • [40] A Phase 1/2, Open-Label, Multiple Ascending Dose Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INZ-701 in Adults with ENPP1 Deficiency
    Sabbagh, Yves
    Wermers, Robert
    Fuhr, Rainard
    Schnabel, Dirk
    Arnason, Terra
    Besancon, Alix
    Cizman, Borut
    Wenkert, Deborah
    Gunter, Kurt
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 72 - 72
12345