Novel small-molecule inhibitors of SARS-CoV-2 main protease with nanomolar antiviral potency

被引:1
|
作者
Zhang, Haoran [1 ,2 ]
Zhou, Kangping [3 ]
Peng, Fei [1 ,2 ]
Gao, Zhao [4 ]
Song, Guowei [4 ]
Hu, Bing [3 ]
Chun, Sophia [4 ]
Xiao, Junfeng [1 ,2 ]
Qian, Mengfei [4 ]
Wu, Jin [4 ]
Pan, Kai [3 ]
Gao, Fan [4 ]
Guo, Meng [3 ]
Peng, Cheng [4 ]
Zou, Gang [4 ]
Wu, Jim Zhen [4 ]
Cai, Kun [3 ]
Li, Yan [1 ,2 ,5 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathogen Biol, 13 Hangkong Rd, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, State Key Lab Diag & Treatment Severe Zoonot Infec, 13 Hangkong Rd, Wuhan, Peoples R China
[3] Hubei Prov Ctr Dis Control & Prevent Hubei CDC, Inst Hlth Inspect & Testing, Wuhan 430079, Peoples R China
[4] Suzhou Ark Biopharmaceut Co Ltd, 218 Xinghu St, Suzhou 215123, Jiangsu, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan 430030, Peoples R China
基金
中国国家自然科学基金;
关键词
D O I
10.1016/j.jinf.2023.12.014
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
引用
收藏
页码:211 / 214
页数:4
相关论文
共 50 条
  • [31] Potent and biostable inhibitors of the main protease of SARS-CoV-2
    Tsuji, Kohei
    Ishii, Takahiro
    Kobayakawa, Takuya
    Higashi-Kuwata, Nobuyo
    Azuma, Chika
    Nakayama, Miyuki
    Onishi, Takato
    Nakano, Hiroki
    Wada, Naoya
    Hori, Miki
    Shinohara, Kouki
    Miura, Yutaro
    Kawada, Takuma
    Hayashi, Hironori
    Hattori, Shin-ichiro
    Bulut, Haydar
    Das, Debananda
    Takamune, Nobutoki
    Kishimoto, Naoki
    Saruwatari, Junji
    Okamura, Tadashi
    Nakano, Kenta
    Misumi, Shogo
    Mitsuya, Hiroaki
    Tamamura, Hirokazu
    ISCIENCE, 2022, 25 (11)
  • [32] Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease
    Katagishi, Daiki
    Yasuda, Daisuke
    Takahashi, Kyoko
    Nakamura, Shigeo
    Mashino, Tadahiko
    Ohe, Tomoyuki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 80
  • [33] Biochemical screening for SARS-CoV-2 main protease inhibitors
    Coelho, Camila
    Gallo, Gloria
    Campos, Claudia B.
    Hardy, Leon
    Wurtele, Martin
    PLOS ONE, 2020, 15 (10):
  • [34] Repurposing an Antiviral Drug against SARS-CoV-2 Main Protease
    Sarkar, Arighna
    Mandal, Kalyaneswar
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (44) : 23492 - 23494
  • [35] Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
    Johansen-Leete, Jason
    Ullrich, Sven
    Fry, Sarah E.
    Frkic, Rebecca
    Bedding, Max J.
    Aggarwal, Anupriya
    Ashhurst, Anneliese S.
    Ekanayake, Kasuni B.
    Mahawaththa, Mithun C.
    Sasi, Vishnu M.
    Luedtke, Stephanie
    Ford, Daniel J.
    O'Donoghue, Anthony J.
    Passioura, Toby
    Larance, Mark
    Otting, Gottfried
    Turville, Stuart
    Jackson, Colin J.
    Nitsche, Christoph
    Payne, Richard J.
    CHEMICAL SCIENCE, 2022, 13 (13) : 3826 - 3836
  • [36] Drug Potency Prediction of SARS-CoV-2 Main Protease Inhibitors Based on a Graph Generative Model
    Fadlallah, Sarah
    Julia, Carme
    Garcia-Vallve, Santiago
    Pujadas, Gerard
    Serratosa, Francesc
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (10)
  • [37] SARS-CoV-2 Resistance to Small Molecule Inhibitors
    Lopez, Uxua Modrego
    Hasan, Md. Mehedi
    Havranek, Brandon
    Islam, Shahidul M.
    CURRENT CLINICAL MICROBIOLOGY REPORTS, 2024, 11 (03): : 127 - 139
  • [38] The Discovery of Novel Small Oxindole-Based Inhibitors Targeting the SARS-CoV-2 Main Protease (Mpro)
    Alzyoud, Lara
    Mahgoub, Radwa E.
    Mohamed, Feda E.
    Ali, Bassam R.
    Ferreira, Juliana
    Rabeh, Wael M.
    Atatreh, Noor
    Ghattas, Mohammad A.
    CHEMISTRY & BIODIVERSITY, 2023, 20 (11)
  • [39] Identification of antiviral phytochemicals from cranberry as potential inhibitors of SARS-CoV-2 main protease (Mpro)
    Pillai, U. Jisha
    Cherian, Lucy
    Taunk, Khushman
    Iype, Eldhose
    Dutta, Mainak
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 261
  • [40] Discovering small-molecule therapeutics against SARS-CoV-2
    Tiwari, Vaibhav
    Beer, Jacob C.
    Sankaranarayanan, Nehru Viji
    Swanson-Mungerson, Michelle
    Desai, Umesh R.
    DRUG DISCOVERY TODAY, 2020, 25 (08) : 1535 - 1544