Immunopathogenesis of viral infections in neurological autoimmune disease

被引：4

作者：

Habibi, Mohammad Amin ^{[1
,2
]}

Nezhad Shamohammadi, Fatemeh ^{[3
]}

Rajaei, Taraneh ^{[4
]}

Namdari, Haideh ^{[5
]}

Pashaei, Mohammad Reza ^{[6
]}

Farajifard, Hamid ^{[2
]}

Ahmadpour, Sajjad ^{[7
]}

机构：

[1] Univ Tehran Med Sci, Neurosci Inst, Multiple Sclerosis Res Ctr, Tehran, Iran

[2] Univ Tehran Med Sci, Gene Cell & Tissue Res Inst, Pediat Cell & Gene Therapy Res Ctr, Tehran, Iran

[3] Shiraz Univ Med Sci, Sch Med, Dept Immunol, Shiraz, Iran

[4] Univ Tehran, Fac Vet Med, Dept Microbiol & Immunol, Tehran, Iran

[5] Univ Tehran Med Sci, Imam Khomeini Hosp, Iranian Tissue Bank & Res Ctr, Tehran, Iran

[6] Urmia Univ Med Sci, Clin Res Inst, Patient Safety Res Ctr, Sch Med, Orumiyeh, Iran

[7] Urmia Univ Med Sci, Clin Res Inst, Patient Safety Res Ctr, Orumiyeh, Iran

来源：

BMC NEUROLOGY | 2023年 / 23卷 / 01期

关键词：

Multiple sclerosis; Autoimmunity; Viral infections; Autoimmune reaction; GUILLAIN-BARRE-SYNDROME; VARICELLA-ZOSTER-VIRUS; NF-KAPPA-B; CD8(+) T-CELLS; MULTIPLE-SCLEROSIS; CEREBROSPINAL-FLUID; INFLUENZA VACCINES; MOLECULAR MIMICRY; TYPE-1; HTLV-1; COVID-19;

D O I：

10.1186/s12883-023-03239-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Autoimmune diseases develop due to self-tolerance failure in recognizing self and non-self-antigens. Several factors play a role in inducing autoimmunity, including genetic and environmental elements. Several studies demonstrated the causative role of viruses; however, some studies showed the preventive effect of viruses in the development of autoimmunity. Neurological autoimmune diseases are classified based on the targets of autoantibodies, which target intracellular or extracellular antigens rather than neurons. Several theories have been hypothesized to explain the role of viruses in the pathogenesis of neuroinflammation and autoimmune diseases. This study reviewed the current data on the immunopathogenesis of viruses in autoimmunity of the nervous system.

引用

页数：15

共 50 条

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Hamid Farajifard
Sajjad Ahmadpour
[J]. BMC Neurology, 23
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