Macrophage-derived biomimetic nanoparticles enhanced SDT combined with immunotherapy inhibited tumor growth and metastasis

被引：21
|
作者：
Chen, Sijie [1 ,2 ,3 ]
Ma, Tianliang [4 ,5 ]
Wang, Jiahao [4 ,5 ]
Liang, Shuailong [4 ,5 ]
Liao, Haiqin [1 ,2 ,3 ]
Tan, Wanlin [1 ,2 ,3 ]
Chen, Mingyu [1 ,2 ,3 ]
Zhou, Xiaohui [6 ]
Xu, Yan [1 ,2 ,3 ]
Wang, Long [4 ,5 ]
Niu, Chengcheng [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Ultrasound Diag, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Res Ctr Ultrasonog, Changsha 410011, Hunan, Peoples R China
[3] Clin Res Ctr Ultrasound Diag & Treatment Hunan Pro, Wuhan, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China
[5] Cent South Univ, Xiangya Hosp, Hunan Engn Res Ctr Biomed Met & Ceram Implants, Changsha, Peoples R China
[6] Nanhua Univ, Changsha Cent Hosp, Dept Ultrasound Diag, Changsha 410014, Hunan, Peoples R China
来源：
BIOMATERIALS | 2024年 / 305卷
基金：
中国国家自然科学基金;
关键词：
M1; macrophage; Sonodynamic therapy; Immune checkpoint blockade; Immune activation; Immunogenic cell death; CANCER-IMMUNOTHERAPY; CHEMOTHERAPY; BLOCKADE; THERAPY; SIGNALS; PD-1;
D O I：
10.1016/j.biomaterials.2023.122456
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Combination therapy based on sonodynamic therapy (SDT) combined with immune checkpoint blockers anti-PDL1 provides effective anti-tumor effects. We designed a combination therapy based on M1/PLGA@IR780/CAT NPs of SDT-enhanced immunity combined with immune checkpoint blockers against PD -L1, which was based on M1 macrophage membrane-encapsulated poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with the acoustic sensitizer IR780 and catalase (CAT) to successfully realize it. SDT based on M1/PLGA@IR780/CAT NPs could induce tumor cell death by promoting dendritic cell (DC) maturation and modulating the tumor immune microenvironment. In particular, the systemic anti-tumor immune response and potent immune memory induced upon combination with anti-PD-L1 checkpoint blockade not only alleviated the progression of mammary cancer in 4T1 mice and effectively blocked distant metastasis, but also prevented tumor recurrence, providing a promising new therapeutic strategy for clinical tumor therapy.
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页数：16
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