Photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access 2,4-disubstituted quinolines

被引：4
|
作者：
Huang, Peng-Fei [1 ]
Fu, Jia-Le [1 ]
Huang, Jia-Jing [1 ]
Xiong, Bi-Quan [1 ]
Tang, Ke-Wen [1 ]
Liu, Yu [1 ]
机构：
[1] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 03期
基金：
中国国家自然科学基金;
关键词：
MULTICOMPONENT REACTIONS; BIOLOGICAL EVALUATION; LIGHT; ISONITRILES; CATALYSIS; INSERTION;
D O I：
10.1039/d3ob01915b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We herein report an efficient photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access a wide range of 2,4-disubstituted quinolines. Preliminary mechanism experiment results suggested that this reaction was initiated by an acyl radical generated from acyl chlorides through a single-electron-transfer (SET) process. This transformation showed good substrate suitability and functional group compatibility at room temperature.
引用
收藏
页码：513 / 520
页数：8
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