Effect of tomato, tomato-derived products and lycopene on metabolic inflammation: from epidemiological data to molecular mechanisms

被引：4
|
作者：
Landrier, Jean-Francois [1 ]
Breniere, Thomas [1 ,2 ,3 ]
Sani, Lea [1 ]
Desmarchelier, Charles [1 ]
Mounien, Lourdes [1 ]
Borel, Patrick [1 ]
机构：
[1] Aix Marseille Univ, INSERM, INRAE, C2VN, Marseille, France
[2] INRAE, Ctr Avignon UR1115 Plantes & Syst Culture Horticol, Avignon, France
[3] Univ Avignon, UPR 4278, Lab Physiol Experimentale Cardiovasc LAPEC, F-84029 Avignon, France
来源：
NUTRITION RESEARCH REVIEWS | 2023年
关键词：
inflammation; liver steatosis; lycopene; metabolic diseases; metabolic inflammation; NF-kB signalling; obesity; tomato; tomato products; type; 2; diabetes; NF-KAPPA-B; PROINFLAMMATORY CYTOKINE CASCADE; NONALCOHOLIC FATTY LIVER; LOW-CAROTENOID DIET; ADIPOSE-TISSUE; OXIDATIVE STRESS; APO-10'-LYCOPENOIC ACID; TNF-ALPHA; CARDIOVASCULAR-DISEASE; JUICE SUPPLEMENTATION;
D O I：
10.1017/S095442242300029X
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The goal of this narrative review is to summarise the current knowledge and limitations related to the anti-inflammatory effects of tomato, tomato-derived products and lycopene in the context of metabolic inflammation associated to cardiometabolic diseases. The potential of tomato and tomato-derived product supplementation is supported by animal and in vitro studies. In addition, intervention studies provide arguments in favour of a limitation of metabolic inflammation. This is also the case for observational studies depicting inverse association between plasma lycopene levels and inflammation. Nevertheless, current data of intervention studies are mixed concerning the anti-inflammatory effect of tomato and tomato-derived products and are not in favour of an anti-inflammatory effect of pure lycopene in humans. From epidemiological to mechanistic studies, this review aims to identify limitations of the current knowledge and gaps that remain to be filled to improve our comprehension in contrasted anti-inflammatory effects of tomato, tomato-derived products and pure lycopene.
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页数：17
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