PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

被引：7

作者：

Dong, Hongmei ^{[1
,2
,3
,4
]}

Lin, Wan ^{[5
]}

Du, Liang ^{[6
]}

Yao, Zhimeng ^{[1
,2
,3
,7
]}

Li, Feifei ^{[8
]}

Chen, Shuanglong ^{[1
,2
,3
]}

Huang, Yiteng ^{[9
]}

Ren, Hongzheng ^{[10
,11
]}

Luo, Yichen ^{[1
,2
,3
]}

Cai, Songwang ^{[12
]}

Chen, Yexi ^{[13
]}

Tang, Hui ^{[14
,15
]}

Qiu, Xiaofu ^{[16
]}

Pan, Yunlong ^{[4
]}

Huang, Xingxu ^{[17
]}

Zhang, Dianzheng ^{[18
]}

Gao, Shegan ^{[19
,23
]}

Yeung, Sai-Ching Jim ^{[20
,21
,24
]}

Zhang, Hao ^{[4
,22
]}

机构：

[1] Jinan Univ, Inst Precis Canc Med & Pathol, Guangzhou, Peoples R China

[2] Jinan Univ, Sch Med, Dept Pathol, Guangzhou, Guangdong, Peoples R China

[3] Jinan Univ, Minister Educ, Key Lab Tumor Mol Biol, Guangzhou, Guangdong, Peoples R China

[4] Jinan Univ, Dept Gen Surg, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[5] Shantou Univ, Canc Res Ctr, Med Coll, Shantou, Guangdong, Peoples R China

[6] Chongqing Univ, Canc Hosp, Radiat Oncol Ctr, Chongqing, Peoples R China

[7] Jinan Univ, Affiliated Hosp 1, Dept Urol Surg, Guangzhou, Guangdong, Peoples R China

[8] Peoples Hosp Leshan, Dept Oncol, Leshan, Sichuan, Peoples R China

[9] Shantou Univ, Hlth Care Ctr, Affiliated Hosp 1, Med Coll, Shantou, Guangdong, Peoples R China

[10] Naval Med Univ, Gongli Hosp, Dept Pathol, Shanghai, Peoples R China

[11] Changzhi Med Coll, Dept Pathol, Heping Hosp, Changzhi, Shanxi, Peoples R China

[12] Jinan Univ, Dept Thorac Surg, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[13] Shantou Univ, Dept Gen Surg, Affiliated Hosp 2, Med Coll, Shantou, Guangdong, Peoples R China

[14] Jinan Univ, Dept Cent Lab, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[15] Jinan Univ, Heyuan Shenhe Peoples Hosp, Dept Clin Lab, Affiliated Hosp 5, Heyuan, Peoples R China

[16] Guangdong Second Prov Gen Hosp, Dept Urol, Guangzhou, Guangdong, Peoples R China

[17] Nanjing Univ, Model Anim Res Ctr, MOE, Key Lab Model Anim Dis Study, Nanjing, Jiangsu, Peoples R China

[18] Philadelphia Coll Osteopath Med, Dept Biomed Sci, Philadelphia, PA USA

[19] Henan Univ Sci & Technol, Coll Clin Med, Affiliated Hosp 1, Henan Key Lab Canc Epigenet, Luoyang 471003, Henan, Peoples R China

[20] Univ Texas MD Anderson Canc Ctr, Dept Emergency Med, Houston, TX USA

[21] Univ Texas MD Anderson Canc Ctr, Dept Endocrine Neoplasia & Hormonal Disorders, Houston, TX USA

[22] Jinan Univ, Dept Gen Surg, Affiliated Hosp 1, 613 Huangpu Ave West, Guangzhou 510630, Guangdong, Peoples R China

[23] Henan Univ Sci & Technol, Coll Clin Med, Affiliated Hosp 1, Henan Key Lab Canc Epigenet, Luoyang 471003, Henan, Peoples R China

[24] Univ Texas MD Anderson Canc Ctr, Dept Emergency Med, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2023年 / 567卷

关键词：

PTPRO; Tyrosine phosphatase; MET; Esophageal squamous cell carcinoma; Metastasis; RECEPTOR-TYROSINE KINASE; C-MET; GENE AMPLIFICATION; LUNG-CANCER; CELL; EGFR; CARCINOGENESIS; METHYLATION; RESISTANCE; MODEL;

D O I：

10.1016/j.canlet.2023.216283

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPROlow/ p-METhigh had significantly poor prognosis, suggesting that PTPROlow/p-METhigh can serve as an independent prognostic factor for patients with ESCC.

引用

页数：10

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