Transition-metal-free Synthesis of tetra-substituted Vinyl Iodides by Cascade Sequential Reaction of a-Keto Acids, 1-Iodoalkynes, and Alkyl Halides

被引：0
|
作者：
Zeng, Xiaobao [1 ]
Cheng, Zhenfeng [1 ]
Xie, Yushan [1 ]
Gu, Yunhui [1 ]
机构：
[1] Nantong Univ, Sch Pharm, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, Nantong 226001, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2023年 / 18卷 / 02期
关键词：
transition-metal-free; cascade sequential reaction; terta-substituted vinyl iodides; 1-iodoalkynes; alpha-keto acids; BAYLIS-HILLMAN ESTERS; GAMMA-HYDROXYBUTENOLIDES; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; DOUBLE-BONDS; ANNULATION; HALOALKYNES; BUTENOLIDES; ACCESS; ARYL;
D O I：
10.1002/asia.202201117
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cascade sequential reaction of alpha-keto acids, 1-iodoalkynes, and alkyl halides are reported herein to synthesize tetra-substituted vinyl iodides. It represents an efficient protocol to access a diverse range of tetra-substituted vinyl iodides starting from simple materials in a one-pot fashion, featuring mild reaction conditions, ease of operation, and broad substrate scope.
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页数：7
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