Preclinical and clinical evaluation of the RAF/MEK clamp avutometinib (VS-6766) in combination with the mTOR inhibitor everolimus for the treatment of KRAS mutated non-small cell lung cancer

被引：0
|
作者：
Rodney, Simon
Stewart, Adam R.
Perez, Victoria Sanchez
Morton, Cienne
Pickard, Lisa A.
Shakouri, Taleen
Prout, Toby
Parmar, Mona
Turner, Alison J.
Coma, Silvia
Pachter, Jonathan
Finneran, Laura
Hall, Emma
Spicer, James
Minchom, Anna
Banerji, Udai
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-3461
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3461
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Phase I trial of the MEK inhibitor selumetinib in combination with thoracic radiotherapy in non-small cell lung cancer
    Haslett, K.
    Koh, P.
    Hudson, A.
    Ryder, W. D.
    Falk, S.
    Mullan, D.
    Taylor, B.
    Califano, R.
    Blackhall, F.
    Faivre-Finn, C.
    CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY, 2021, 28 : 24 - 31
  • [22] Dual inhibition of MEK and p38 impairs tumor growth in KRAS-mutated non-small cell lung cancer
    Sunaga, Noriaki
    Miura, Yosuke
    Tsukagoshi, Yusuke
    Kasahara, Norimitsu
    Masuda, Tomomi
    Sakurai, Reiko
    Kaira, Kyoichi
    Hisada, Takeshi
    ONCOLOGY LETTERS, 2019, 17 (03) : 3569 - 3575
  • [23] Dissecting the Clinical Characteristics and Treatment Outcomes Correlates of KRAS G12C-Mutated Non-Small Cell Lung Cancer
    Jing, Yawan
    Cheng, Ruixin
    Zeng, Hao
    Huang, Qin
    He, Dongyu
    Sun, Jiayi
    Tian, Panwen
    Li, Yalun
    INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2024, 17 : 4507 - 4517
  • [24] KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target
    Roman, Marta
    Baraibar, Iosune
    Lopez, Ines
    Nadal, Ernest
    Rolfo, Christian
    Vicent, Silvestre
    Gil-Bazo, Ignacio
    MOLECULAR CANCER, 2018, 17
  • [25] KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target
    Marta Román
    Iosune Baraibar
    Inés López
    Ernest Nadal
    Christian Rolfo
    Silvestre Vicent
    Ignacio Gil-Bazo
    Molecular Cancer, 17
  • [26] ENGOT-ov60/GOG-3052/RAMP 201: A phase 2 study of VS-6766 (RAF/MEK clamp) alone and in combination with defactinib (FAK inhibitor) in recurrent low-grade serous ovarian cancer (LGSOC).
    Banerjee, Susana N.
    Monk, Bradley J.
    Van Nieuwenhuysen, Els
    Moore, Kathleen N.
    Oaknin, Ana
    Fabbro, Michel
    Colombo, Nicoletta
    O'Malley, David M.
    Coleman, Robert L.
    Oza, Amit M.
    Pachter, Jonathan A.
    Patrick, Gloria
    Denis, Louis J.
    Leonard, Lorna
    Grisham, Rachel N.
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [27] Clinical Characteristics and Outcomes in Patients With KRAS G12C Mutated Non-Small Cell Lung Cancer
    Pellini, B.
    Ganesan, V.
    Wan, F.
    Sankararaman, S.
    Manyanont, S.
    Akhave, N.
    Baggstrom, M.
    Ward, J.
    Waqar, S.
    Morgensztern, D.
    Govindan, R.
    Devarakonda, S.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : S209 - S210
  • [28] The Relationship Between Genomic Alterations and the Efficacy of Immune Check Point Inhibitor for KRAS Mutated Non-Small Cell Lung Cancer
    Furuya, N.
    Kakinuma, K.
    Morikawa, K.
    Inoue, T.
    Mineshita, M.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : S330 - S330
  • [29] Downregulation of 18F-FDG Uptake in PET as an Early Pharmacodynamic Effect in Treatment of Non-Small Cell Lung Cancer with the mTOR Inhibitor Everolimus
    Nogova, Lucia
    Boellaard, Ronald
    Kobe, Carsten
    Hoetjes, Nikie
    Zander, Thomas
    Gross, Stefan Hubert
    Dimitrijevic, Sasa
    Pellas, Theodore
    Eschner, Wolfgang
    Schmidt, Katja
    Bangard, Christopher
    Hayes, Wendy
    Thomas, Roman K.
    Dietlein, Markus
    Giaccone, Giuseppe
    Hoekstra, Otto S.
    Lammertsma, Adriaan A.
    Wolf, Juergen
    JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (11) : 1815 - 1819
  • [30] Multi-kinase RET inhibitor vandetanib combined with mTOR inhibitor everolimus in patients with RET rearranged non-small cell lung cancer.
    Subbiah, Vivek
    Cascone, Tina
    Hess, Kenneth R.
    Subbiah, Ishwaria Mohan
    Nelson, Sarah
    Morikawa, Naoto
    Nilsson, Monique B.
    Bhatt, Tarak
    Ali, Siraj
    William, William Nassib
    Raymond, Victoria M.
    Lanman, Richard B.
    Carbone, David Paul
    Salgia, Ravi
    Owonikoko, Taofeek Kunle
    Simon, George R.
    Meric-Bernstam, Funda
    Doebele, Robert Charles
    Heymach, John
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
12345