Wnt-β-catenin in hepatobiliary homeostasis, injury, and repair

被引：12

作者：

Nejak-Bowen, Kari ^{[1
,2
,4
,5
]}

Monga, Satdarshan P. ^{[1
,2
,3
,6
,7
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Pathol, Div Expt Pathol, Pittsburgh, PA USA

[2] Univ Pittsburgh, Pittsburgh Liver Res Ctr, Med Ctr, Pittsburgh, PA USA

[3] Univ Pittsburgh, Sch Med, Dept Med Hepatol & Nutr, Div Gastroenterol, Pittsburgh, PA USA

[4] Univ Pittsburgh, Sch Med, Dept Pathol, 200 Lothrop St S-405A BST, Pittsburgh, PA 15261 USA

[5] UPMC, 200 Lothrop St S-405A BST, Pittsburgh, PA 15261 USA

[6] Univ Pittsburgh, Sch Med, 200 Lothrop St S-422 BST, Pittsburgh, PA 15261 USA

[7] UPMC, 200 Lothrop St S-422 BST, Pittsburgh, PA 15261 USA

来源：

HEPATOLOGY | 2023年 / 78卷 / 06期

关键词：

METABOLIC LIVER ZONATION; BILE-ACID METABOLISM; WNT/BETA-CATENIN; THYROID-HORMONE; HEPATOCYTE PROLIFERATION; SCLEROSING CHOLANGITIS; GAMMA-CATENIN; FATTY LIVER; RAT HEPATOCYTES; DUCT LIGATION;

D O I：

10.1097/HEP.0000000000000495

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Wnt-beta-catenin signaling has emerged as an important regulatory pathway in the liver, playing key roles in zonation and mediating contextual hepatobiliary repair after injuries. In this review, we will address the major advances in understanding the role of Wnt signaling in hepatic zonation, regeneration, and cholestasis-induced injury. We will also touch on some important unanswered questions and discuss the relevance of modulating the pathway to provide therapies for complex liver pathologies that remain a continued unmet clinical need.

引用

页码：1907 / 1921

页数：15

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