Noninvasive Stereotactic Radiotherapy for PADN in an Acute Canine Model of Pulmonary Arterial Hypertension

被引：1

作者：

Xu, Wei ^{[1
]}

Wang, Ding-yu ^{[1
]}

Chen, Zi-yin ^{[2
]}

Gao, Qiang ^{[1
]}

Zou, Yi-lun ^{[1
]}

Sun, Dang-hui ^{[1
]}

Zhang, Song ^{[1
]}

Zhao, Xin-bo ^{[1
]}

Gong, Yong-tai ^{[1
]}

Zhang, Yun ^{[1
]}

Zhang, Da-xin ^{[1
,2
]}

Li, Yue ^{[1
,3
,4
,5
,6
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Youzheng St 23, Harbin 150001, Heilongjiang Pr, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 1, Dept Orthopaed, Harbin, Peoples R China

[3] Harbin Med Univ, Natl Key Lab Frigid Zone Cardiovasc Dis, Harbin, Peoples R China

[4] Harbin Med Univ, NHC Key Lab Cell Transplantat, Harbin, Heilongjiang, Peoples R China

[5] Heilongjiang Acad Med Sci, Inst Metab Dis, Harbin, Peoples R China

[6] Harbin Med Univ, Affiliated Hosp 1, Heilongjiang Prov Clin Med Res Ctr Hypertens, Harbin, Peoples R China

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2024年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

pulmonary arterial hypertension; pulmonary artery; pulmonary artery denervation; noninvasive stereotactic body radiotherapy; DENERVATION; ACTIVATION; RADIATION;

D O I：

10.1016/j.jacbts.2023.09.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study assesses the feasibility, safety, and effectiveness of noninvasive stereotactic body radiotherapy (SBRT) as an approach for pulmonary artery denervation in canine models. SBRT with CyberKnife resulted in reduced mean pulmonary artery pressure, pulmonary capillary wedge pressure, and pulmonary vascular resistance, and insignificantly increased cardiac output. In comparison to the control group, serum norepinephrine levels at 1 month and 6 months were significantly lower in the CyberKnife group. Computed tomography, pulmonary angiography, and histology analysis revealed that SBRT was associated with minimal collateral damage. (J Am Coll Cardiol Basic Trans Science 2024;9:244-256) (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：244 / 256

页数：13

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