Meningeal regulation of infections: A double-edged sword

In the past 10 years, important discoveries have been made in the field of neuroimmunology, especially regarding brain borders. Indeed, meninges are protective envelopes surrounding the CNS and are currently in the spotlight, with multiple studies showing their involvement in brain infection and cognitive disorders. In this review, we describe the meningeal layers and their protective role in the CNS against bacterial, viral, fungal, and parasitic infections, by immune and nonimmune cells. Moreover, we discuss the neurological and cognitive consequences resulting from meningeal infections in neonates (e.g. infection with group B Streptococcus, cytomegalovirus, horizontal ellipsis ) or adults (e.g. infection with Trypanosoma brucei, Streptococcus pneumoniae, horizontal ellipsis ). We hope that this review will bring to light an integrated view of meningeal immune regulations during CNS infections and their neurological consequences.