Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury

被引：1

作者：

Taquet, Maxime ^{[1
,2
]}

Skorniewska, Zuzanna ^{[1
]}

Zetterberg, Henrik ^{[3
,4
,5
,6
,7
,8
]}

Geddes, John R. ^{[1
,2
]}

Mummery, Catherine J. ^{[5
]}

Chalmers, James D. ^{[9
]}

Ho, Ling-Pei ^{[10
]}

Horsley, Alex ^{[11
,12
]}

Marks, Michael ^{[13
,14
,15
]}

Poinasamy, Krisnah ^{[16
]}

Raman, Betty ^{[17
,18
]}

Leavy, Olivia C. ^{[19
]}

Richardson, Matthew ^{[20
]}

Elneima, Omer ^{[20
]}

McAuley, Hamish J. C. ^{[20
]}

Shikotra, Aarti ^{[21
]}

Singapuri, Amisha ^{[20
]}

Sereno, Marco ^{[20
]}

Saunders, Ruth M. ^{[20
]}

Harris, Victoria Claire ^{[20
,22
]}

Houchen-Wolloff, Linzy ^{[23
,24
,25
]}

Mansoori, Parisa ^{[26
]}

Greening, Neil J. ^{[20
]}

Harrison, Ewen M. ^{[27
]}

Docherty, Annemarie B. ^{[27
]}

Lone, Nazir I. ^{[28
,29
]}

Quint, Jennifer ^{[30
]}

Greenhalf, William ^{[31
,32
,33
]}

Wain, Louise V. ^{[19
,20
]}

Brightling, Christopher E. ^{[20
]}

Evans, Rachael E. ^{[20
,22
]}

Harrison, Paul J. ^{[1
,2
]}

Koychevon, Ivan ^{[1
]}

机构：

[1] Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England

[2] Oxford Hlth NHS Fdn Trust, Oxford OX3 7JX, England

[3] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, S-41390 Molndal, Sweden

[4] Sahlgrens Univ Hosp, Clin Neurochem Lab, S-43180 Molndal, Sweden

[5] UCL Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3BG, England

[6] UCL, UK Dementia Res Inst, London WC1N 3BG, England

[7] Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

[8] Univ Wisconsin Madison, Wisconsin Alzheimers Dis Res Ctr, Sch Med & Publ Hlth, Univ Wisconsin, Madison, WI 53792 USA

[9] Univ Dundee, Ninewells Hosp & Med Sch, Dundee DD1 9SY, Scotland

[10] Univ Oxford, MRC Human Immunol Unit, Oxford OX3 9DS, England

[11] Univ Manchester, Fac Biol Med & Hlth, Div Infect Immun & Resp Med, Manchester M13 9PL, Lancs, England

[12] Manchester Univ NHS Fdn Trust, Manchester M13 9WL, Lancs, England

[13] London Sch Hyg & Trop Med, Dept Clin Res, London WC1E 7HT, England

[14] Univ Coll London Hosp, Hosp Trop Dis, London WC1E 6JD, England

[15] UCL, Div Infect & Immun, London WC1E 6BT, England

[16] Asthma & Lung UK, London E1 8AA, England

[17] Univ Oxford, Radcliffe Dept Med, Oxford OX3 9DU, England

[18] Oxford Univ Hosp NHS Fdn Trust, Oxford OX3 9DU, England

[19] Univ Leicester, Dept Populat Hlth Sci, Leicester LE1 7RH, Leics, England

[20] Univ Leicester, Inst Lung Hlth, NIHR Leicester Biomed Res Ctr, Leicester LE3 9QP, Leics, England

[21] Univ Leicester, NIHR Leicester Biomed Res Ctr, Leicester LE5 4PW, Leics, England

[22] Univ Hosp Leicester NHS Trust, Leicester LE5 4PW, Leics, England

[23] Univ Leicester, NIHR Leicester Biomed Res Ctr Resp, Ctr Exercise & Rehabil Sci, Leicester LE5 4PW, Leics, England

[24] Univ Leicester, Dept Resp Sci, Leicester LE1 9HN, Leics, England

[25] Univ Hosp Leicester NHS Trust, Therapy Dept, Leicester LE5 4PW, Leics, England

[26] MQ Transforming Mental Hlth, London EC1Y 0TH, England

[27] Univ Edinburgh, Usher Inst, Ctr Med Informat, Edinburgh EH16 4SS, Midlothian, Scotland

[28] Univ Edinburgh, Usher Inst, Edinburgh EH16 4SS, Midlothian, Scotland

[29] Royal Infirm Edinburgh NHS Trust, NHS Lothian, Edinburgh EH16 4SA, Midlothian, Scotland

[30] Imperial Coll London, Natl Heart & Lung Inst, London SW3 6LY, England

[31] Univ Liverpool, Liverpool L69 3BX, Merseyside, England

[32] CRUK Liverpool Expt Canc Med Ctr, Liverpool L69 3GL, Merseyside, England

[33] Liverpool Univ Hosp NHS Fdn Trust, Liverpool L7 8YE, Merseyside, England

来源：

BRAIN COMMUNICATIONS | 2023年 / 6卷 / 01期

基金：

英国科研创新办公室;

关键词：

neural injury; long COVID; biomarkers;

D O I：

10.1093/braincomms/fcad357

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A proportion of patients infected with severe acute respiratory syndrome coronavirus 2 experience a range of neuropsychiatric symptoms months after infection, including cognitive deficits, depression and anxiety. The mechanisms underpinning such symptoms remain elusive. Recent research has demonstrated that nervous system injury can occur during COVID-19. Whether ongoing neural injury in the months after COVID-19 accounts for the ongoing or emergent neuropsychiatric symptoms is unclear. Within a large prospective cohort study of adult survivors who were hospitalized for severe acute respiratory syndrome coronavirus 2 infection, we analysed plasma markers of nervous system injury and astrocytic activation, measured 6 months post-infection: neurofilament light, glial fibrillary acidic protein and total tau protein. We assessed whether these markers were associated with the severity of the acute COVID-19 illness and with post-acute neuropsychiatric symptoms (as measured by the Patient Health Questionnaire for depression, the General Anxiety Disorder assessment for anxiety, the Montreal Cognitive Assessment for objective cognitive deficit and the cognitive items of the Patient Symptom Questionnaire for subjective cognitive deficit) at 6 months and 1 year post-hospital discharge from COVID-19. No robust associations were found between markers of nervous system injury and severity of acute COVID-19 (except for an association of small effect size between duration of admission and neurofilament light) nor with post-acute neuropsychiatric symptoms. These results suggest that ongoing neuropsychiatric symptoms are not due to ongoing neural injury. COVID-19 is associated with raised neural injury markers and neuropsychiatric sequelae. It is unknown whether post-acute neural injury is linked to neuropsychiatric symptoms. Taquet et al. showed that there was no robust link between the two, suggesting that neuropsychiatric symptoms of post-acute COVID illness are not caused by ongoing neural injury. Graphical Abstract

引用

页数：9

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