Effect of 226Ra purity as a target for 225Ac production using a fast reactor

被引：0

作者：

Sasaki, Yuto ^{[1
]}

Maeda, Shigetaka ^{[1
]}

机构：

[1] Japan Atom Energy Agcy, Oarai Res & Dev Inst, 4002 Narita, Ibaraki 3111393, Japan

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2024年 / 333卷 / 11期

关键词：

Radioisotope production; Targeted alpha therapy; Ac-225; Fast reactor; Joyo; Ra-226; Fast neutron; (n; 2n); Reaction; MK-III; PROTONS;

D O I：

10.1007/s10967-024-09397-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Researchers are seeking alternative Ac-225 production methods because of the scarcity of Ac-225 for targeted alpha therapy. Although Ra-226 from waste sources has been considered, obtaining( 226)Ra is challenging. Therefore, the authors focused on the contamination of minerals with Th-232-derived Ra-228 while investigating methods to recover Ra-226 from uranium ores. The effect of( 228)Ra contamination on Ac-225 production by Ra-226 transmutation using fast reactors was evaluated. Consequently, toxic Ac-228 contaminates Ac-225. However, using the different half-lives of Ac-225 and Ac-228, pure Ac-225 can be obtained from the chemical separation of actinium after cooling for 5-8 days.

引用

页码：5987 / 5996

页数：10

共 36 条

[21] Neutronic Study on Ac-225 Production for Cancer Therapy by (n,2n) Reaction of Ra-226 or Th-230 Using Fast Reactor Joyo
Iwahashi, Daiki
Kawamoto, Kota
Sasaki, Yuto
Takaki, Naoyuki
PROCESSES, 2022, 10 (07)
[22] Energy resolution improvement in simplified alpha spectroscopy for radionuclidic purity tests on 225Ac production floors
Mihei, Yuma
Tani, Kotaro
Ichinose, Jun
Nagatsu, Kotaro
Fukushi, Masahiro
Kurihara, Osamu
Inoue, Kazumasa
RADIATION PROTECTION DOSIMETRY, 2024, 200 (15) : 1443 - 1449
[23] Production of high-purity α-emitting 225Ac and 213Bi radionuclides for use in nuclear medicine
Guseva L.I.
Radiochemistry, 2013, 55 (3) : 317 - 323
[24] Production of Ac-225 for cancer therapy by photon-induced transmutation of Ra-226
Melville, G.
Meriarty, H.
Metcalfe, P.
Knittel, T.
Allen, B. J.
APPLIED RADIATION AND ISOTOPES, 2007, 65 (09) : 1014 - 1022
[25] 225Ac and 223Ra production via 800 MeV proton irradiation of natural thorium targets
Weidner, J. W.
Mashnik, S. G.
John, K. D.
Ballard, B.
Birnbaum, E. R.
Bitteker, L. J.
Couture, A.
Fassbender, M. E.
Goff, G. S.
Gritzo, R.
Hemez, F. M.
Runde, W.
Ullmann, J. L.
Wolfsberg, L. E.
Nortier, F. M.
APPLIED RADIATION AND ISOTOPES, 2012, 70 (11) : 2590 - 2595
[26] Determination of 226Ra at low levels in environmental, urine, and human bone samples and 223Ra in bone biopsy using alpha-spectrometry and metrological traceability to 229Th/225Ra or 226Ra
Straub, Marietta
Pittet, Pierre-Andre
Amzalag, Gael
Bochud, Francois
Baechler, Sebastien
Froidevaux, Pascal
ANALYTICA CHIMICA ACTA, 2018, 1031 : 178 - 184
[27] Potential production of Ac-225 at Egyptian second research reactor (ETRR-2) through neutron induced transmutation of Ra-226
Gizawy, Mohamed A.
Mohamed, Nader M. A.
APPLIED RADIATION AND ISOTOPES, 2024, 205
[28] A theoretical model for the production of Ac-225 for cancer therapy by neutron capture transmutation of Ra-226
Melville, G.
Melville, P.
APPLIED RADIATION AND ISOTOPES, 2013, 72 : 152 - 157
[29] Production experiments for 225Ac using an electron linear accelerator and radiolabeling tests using the produced alpha emitter
Maeda, M.
Tadokoro, T.
Ueno, Y.
Nishida, K.
Kani, Y.
Sasaki, T.
Watanabe, T.
Kikunaga, H.
Kashiwagi, S.
Shirasaki, K.
Sekimoto, S.
Ohtsuki, T.
Inagaki, M.
Fukutani, S.
Shibahara, Y.
Fujii, H.
Yoshimoto, M.
Ohnuki, K.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 49 (SUPPL 1) : S33 - S34
[30] A theoretical model for the production of Ac-225 for cancer therapy by photon-induced transmutation of Ra-226
Melville, G.
Liu, Sau Fan
Allen, B. J.
APPLIED RADIATION AND ISOTOPES, 2006, 64 (09) : 979 - 988

← 1 2 3 4 →