The relationship between second-trimester amniotic fluid CRP levels and pregnancy outcomes

Aim: The aim of this study is to investigate the relationship between CRP levels studied in second-trimester amniotic fluid and pregnancy outcomes. Material and Methods: Seventy-three single pregnant women who underwent amniocentesis for genetic purposes in our perinatology clinic between 16-22 weeks of gestation and gave birth in our hospital were included in the study. Pregnancies resulting in preterm birth (PTB), preeclampsia, preterm premature rupture of membranes (PPROM), gestational diabetes mellitus (GDM) and postterm pregnancies were defined as "composite outcomes" and these patients were evaluated as Group 1. In addition, patients in Group 1 were divided into five subgroups: PTB, preeclampsia, GDM, PEMR, postterm pregnancies. On the other hand, pregnant women with normal pregnancy outcomes were included in Group 2. All recorded data of these groups were compared. Results: Amniotic fluid CRP level was 0.10 +/- 0.18 mg / L in Group 1 and 0.07 +/- 0.08 mg / L in Group 2 (p: 0.94). In Group 2, gestational age and fetal birth weight were higher. However, this difference was not significant. When CRP values in individual subgroups were compared in terms of composite results (preeclampsia, PTB, GDM, PPROM and postterm pregnancy), amniotic fluid CRP levels were higher than in the general population. Discussion: Our study presented evidence that second-trimester amniotic fluid CRP level is not associated with PD, PPROM, preeclampsia, postterm pregnancy and GDM, which we consider as composite obstetric outcomes.