Electrochemically Promoted Three-Component Reaction to N-Sulfonyl Amidines

被引：4

作者：

Zhang, Zhang ^{[1
]}

Meng, Xiu-Jin ^{[2
]}

Cui, Fei-Hu ^{[2
,3
]}

Tang, Hai-Tao ^{[2
]}

Wang, Ying-Chun ^{[1
]}

Huang, Guo-Bao ^{[3
]}

Pan, Ying-Ming ^{[2
]}

机构：

[1] Jishou Univ, Coll Chem & Chem Engn, Jishou 416000, Peoples R China

[2] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[3] Yulin Normal Univ, Coll Chem & Food Sci, Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 26卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; INHIBITORS; METHANOL;

D O I：

10.1021/acs.orglett.3c03820

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, a multicomponent reaction via the Mannich intermediate was developed using methanol, secondary amine, and sulfonamide as starting materials. This method uses methanol as a green C1 source. The substrate scope is wide, and the yield is good. The mechanistic study shows that methanol generates formaldehyde under electrochemical conditions, and sulfonyl amidine as a nucleophile reacts with Schiff base intermediates to form N-sulfonyl amidine in a single step.

引用

页码：193 / 197

页数：5

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