N-Sulfonyl acetylketenimine as a highly reactive intermediate for the synthesis of N-sulfonyl amidines

被引：40
|
作者：
Yang, Weiguang [1 ]
Huang, Dayun [1 ]
Zeng, Xiaobao [1 ]
Luo, Dongping [1 ]
Wang, Xinyan [1 ]
Hu, Yuefei [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 59期
基金：
中国国家自然科学基金;
关键词：
AZIDE-ALKYNE CYCLOADDITION; ONE-POT SYNTHESIS; COPPER-CATALYZED REACTION; LIGAND-FREE; CONTROLLING SELECTIVITY; CYCLIC AMIDINES; MILD CONDITIONS; DERIVATIVES; CHEMISTRY; DESIGN;
D O I：
10.1039/c8cc04699a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly reactive intermediate N-sulfonyl acetylketenimine was generated from a 3-butyn-2-one participating CuAAC/ring-opening method. Its high reactivity due to bearing two EWGs allowed us to offer the first example of a reaction between ketenimine and amide to synthesize N-sulfonyl amidines efficiently.
引用
收藏
页码：8222 / 8225
页数：4
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