Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

被引：5
|
作者：
Castedo, Maria [1 ,2 ]
Lafarge, Antoine [1 ,2 ,3 ]
Kroemer, Guido [1 ,2 ,4 ]
机构：
[1] Sorbonne Univ, Univ Paris Cite, Ctr Rech Cordeliers, Equipe 11 Labellisee Ligue Canc,INSERM U1138, F-75006 Paris, France
[2] Metabol & Cell Biol Platforms, Gustave Roussy Canc Campus, Villejuif, France
[3] Univ Paris Saclay, Fac medecine, Le Kremlin Bicetre, France
[4] Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Inst Canc Paris CARPEM, Dept Biol, Paris, France
来源：
CELL STRESS | 2023年 / 7卷 / 01期
关键词：
PARP1; inhibition; DNA damage; parthanatos; cancer; neurological diseases; aging; cellular stress response; PARP; INHIBITION; NECROSIS; MITOCHONDRIAL; ACTIVATION; CISPLATIN; APOPTOSIS; ELEGANS;
D O I：
10.15698/cst2023.01.275
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhi-bition protects mice against cerebral ischemia and Parkin-son's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhi-bition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.
引用
收藏
页码：1 / 6
页数：6
相关论文
共 50 条
  • [21] Poly(ADP-ribose) polymerase, its potential role in neuronal death
    Boulu, RG
    Mesenge, C
    Charriaut-Marlangue, C
    Verrecchia, C
    Plotkine, M
    BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2001, 185 (03): : 555 - 565
  • [22] An assessment of poly (ADP-ribose) polymerase-1 role in normal and cancer cells
    Kumar, Manoj
    Jaiswal, Rishi Kumar
    Yadava, Pramod K.
    Singh, Rana P.
    BIOFACTORS, 2020, 46 (06) : 894 - 905
  • [23] Bioenergetic consequences of poly(ADP-ribose) polymerase-1 activation
    Tang, K. S.
    Suh, S. W.
    Swanson, R. A.
    Anderson, C. M.
    PROCEEDINGS OF THE VIII EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, 2007, : 113 - +
  • [24] Niacin, poly(ADP-ribose) polymerase-1 and genomic stability
    Hageman, GJ
    Stierum, RH
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2001, 475 (1-2) : 45 - 56
  • [25] Electrochemical Methods for the Detection of Poly(ADP-ribose) Polymerase-1
    Sun, Ting
    Li, Yanying
    Zhao, Feng
    INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2021, 16 (09): : 1 - 9
  • [26] Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain
    Poitras, M. F.
    Koh, D. W.
    Yu, S.-W.
    Andrabi, S. A.
    Mandir, A. S.
    Poirier, G. G.
    Dawson, V. L.
    Dawson, T. M.
    NEUROSCIENCE, 2007, 148 (01) : 198 - 211
  • [27] Poly (ADP-ribose) Polymerase-1 modulations in the genesis of thrombosis
    Safdar, Raishal
    Mishra, Aastha
    Shah, Girish M.
    Ashraf, Mohammad Zahid
    JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2024, 57 (05) : 743 - 753
  • [28] Poly ADP-ribose polymerase-1: An international molecule of mystery
    Woodhouse, Bethany C.
    Dianov, Grigory L.
    DNA REPAIR, 2008, 7 (07) : 1077 - 1086
  • [29] Poly(ADP-ribose) polymerase-1 as a target for drug development
    Masutani, Mitsuko
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118 : 31P - 31P
  • [30] Poly(ADP-ribose) polymerase-1 in acute neuronal death and inflammation - A strategy for neuroprotection
    Skaper, SD
    NEUROPROTECTIVE AGENTS, 2003, 993 : 217 - 228
12345