Fighting Against the Clock: Circadian Disruption and Parkinson's Disease

被引：2

作者：

Chen, Yen -Chung ^{[1
,2
]}

Wang, Wei-Sheng ^{[1
]}

Lewis, Simon J. G. ^{[3
,6
]}

Wu, Shey-Lin ^{[1
,4
,5
]}

机构：

[1] Changhua Christian Hosp, Dept Neurol, Changhua, Taiwan

[2] Chung Shan Med Univ, Dept Publ Hlth, Taichung, Taiwan

[3] Univ Sydney, Brain & Mind Ctr, Sch Med Sci, Camperdown, NSW, Australia

[4] Natl Changhua Univ Educ, Dept Elect Engn, Changhua, Taiwan

[5] Changhua Christian Hosp, Dept Neurol, 135 Nanhsiao St, Changhua 500, Taiwan

[6] Univ Sydney, Brain & Mind Ctr, Sch Med Sci, Camperdown, NSW 2006, Australia

来源：

JOURNAL OF MOVEMENT DISORDERS | 2024年 / 17卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Circadian clocks; Parkinson disease; Circadian rhythm; Gastrointestinal microbiome; Feedback; BLOOD-BRAIN-BARRIER; SUPRACHIASMATIC NUCLEUS; NONMOTOR SYMPTOMS; BODY-TEMPERATURE; MAMMALIAN CLOCK; ACTIVITY RHYTHM; PERIOD PROTEIN; GANGLION-CELLS; MELATONIN; SLEEP;

D O I：

10.14802/jmd.23216

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Circadian disruption is being increasingly recognized as a critical factor in the development and progression of Parkinson's disease (PD). This review aims to provide an in-depth overview of the relationship between circadian disruption and PD by exploring the molecular, cellular, and behavioral aspects of this interaction. This review will include a comprehensive understanding of how the clock gene system and transcription-translation feedback loops function and how they are diminished in PD. The article also discusses the role of clock genes in the regulation of circadian rhythms, as well as the impact of clock gene dysregulation on mitochondrial function, oxidative stress, and neuroinflammation, including the microbiota-gut-brain axis, which have all been proposed as being crucial mechanisms in the pathophysiology of PD. Finally, this review highlights potential therapeutic strategies targeting the clock gene system and circadian rhythm for the treatment of PD.

引用

页码：1 / 14

页数：14

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